hCFB
品系全名
C57BL/6Smoc-Cfbtm1(hCFB)/Smoc
目录号
NM-HU-2000078
品系状态
活体
基因信息
基因名
品系描述
验证数据
Fig1. Detection of CFB expression in liver by RT-PCR.
Wild type: only one band at 441 bp with primers F1/R1(mCfb);
Homozygous: only one band at 442 bp with primers F2/R2(hCFB);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig2. Detection of human and mouse CFB expression in serum by ELISA (n=2).
Abbr. HO, homozygous; WT, wild type.
Note: The mouse CFB ELISA kit cross-reacted with mCFB and humanized CFB.
Fig3. Detection of liver CFB mRNA remaining at Day 7 (A) and serum protein level (B) after single dose of test drug (n=3/group). (Data from a collaborator)
Fig4. H&E Staining of kidney after single dose of test drug.(Data from a collaborator)
A: normal glomeruli; B: normal interstitial; C: mesangial cell proliferation, crescent body, with inflammation (black arrow); D: renal interstitial inflammation, monocyte aggregation (white arrow); E&F: mild interstitial inflammation in some areas (green arrow), mostly normal.
你也可能感兴趣
Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
查看