Tnfrsf1a/Tnfrsf1b-KO

品系全名

C57BL/6JSmo-Tnfrsf1aem1Tnfrsf1bem1Smoc

目录号

NM-KO-18036

品系状态

胚胎冻存

导出PDF

品系描述

该品系也叫p55/p75 KO。敲除Tnfrsf1a基因的exon 2-5区域，同时敲除Tnfrsf1b基因的exon2，获得Tnfrsf1a和Tnfrsf1b双基因敲除小鼠模型。Tnfrsf1a和Tnfrsf1b缺失（也就是p55和p75缺陷）纯合子小鼠可存活并可育，这些双敲除纯合子小鼠不能结合TNF（tumor necrosis factor）。

发表文献 1篇

1. Inactivation of Tnf-α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice
发表年份：2024 来源杂志：JOR Spine

展开

你也可能感兴趣

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

查看

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

查看

Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

查看