Myf5-Cre

A Cre-WPRE-polyA expression cassette was knocked into the Myf5 gene start codon site. Myogenic factor 5 (Myf5) belongs to the MRF family transcription factors that regulate myogenesis. It is expressed in the skeletal muscle and satellite cells. Severe loss of skeletal muscle following ablation of Myf5-expressing progenitors. This strain is useful in studying the differentiation of skeletal muscle.

Fig. 1 Cre-mediated recombination in the skeletal muscle of Myf5^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle cells of Myf5^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Myf5^Cre/+; Rosa26^tdTomato/+ mice. Tdtomato was expressed in the skeletal muscle. TdTomato can also be detected in individual cells of the brain, pituitary gland, eyes, salivary gland, heart, liver, spleen, lung, kidney, colon, intestine, stomach, pancreas, reproductive system and skin. (For more detailed information please contact our technical advisor.)