hCD3EDG/hBCMA

品系全名

C57BL/6JSmo-Tnfrsf17tm1(hBCMA)Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Smoc

目录号

NM-XA-253164

品系状态

活体

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品系描述

通过hBCMA(NM-HU-200228)与hCD3EDG(NM-HU-220120)小鼠交配获得。

验证数据

image.png

Fig.1 Detection of hBCMA expression on TACI+CD138+ cells in spleen and bone marrow of WT C57BL/6 mice and HO hCD3EDG/hBCMA mice by FACS. hBCMA was exclusively detectable in hCD3EDG/hBCMA humanized mice but not in wild-type mice. hBCMA was exclusively detectable on TACI+CD138+ cells in hBCMA humanized mice. Leukocytes were collected from wild-type C57BL/6 mice (female, 8 weeks old) and homozygous hCD3EDG/hBCMA humanized mice (female, 12 weeks old), and analyzed by flow cytometry with anti-hBCMA. 

Abbr. HO, homozygous; WT, wild type.

2c541d65-6497-41e0-b79a-7e02f857f2da.png

Fig 2. In vivo efficacy study of teclistamab in HO hCD3EDG/hBCMA mice. 

Teclistamab were injected at day 0, 3, 5,  and immune cells in the spleen and bone marrow of mice after therapy were measured by flow cytometry (n=2). Values are shown as mean ± SEM.

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