Tmem173-Flox

品系全名

B6;129S-Tmem173tm1(flox)Smoc

目录号

NM-CKO-00014

品系状态

活体

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品系描述

分别于3号外显子之前和5号外显子后插入loxp位点。若与Cre品系小鼠交配的后代可在Cre酶表达的组织中条件性敲除该基因。 去除neo基因状态活体。
应用领域：细胞凋亡、免疫应答等免疫系统相关研究

发表文献 10篇

1. Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
发表年份：2024 来源杂志：Theranostics

2. Deletion of stimulator of interferons genes aggravated cardiac dysfunction in physiological aged mice
发表年份：2024 来源杂志：MECHANISMS OF AGEING AND DEVELOPMENT

3. Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
发表年份：2023 来源杂志：Military Medical Research

4. Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury
发表年份：2023 来源杂志：Advanced Science

5. STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease
发表年份：2023 来源杂志：MOLECULAR THERAPY

6. Original research: Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation
发表年份：2023 来源杂志：Journal for ImmunoTherapy of Cancer

7. Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis
发表年份：2022 来源杂志：Advanced Science

8. A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion
发表年份：2022 来源杂志：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

9. XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression
发表年份：2022 来源杂志：JHEP Reports

10. Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
发表年份：2021 来源杂志：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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