hIL2RB

品系全名

C57BL/6JSmo-Il2rbtm1(hIL2RB)/Smoc

目录号

NM-HU-2000055

品系状态

胚胎冻存

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基因信息

基因名
IL2RB

品系描述

通过同源重组,将小鼠Il2rb基因进行人源化修饰。
应用领域:细胞因子人源化模型;药物筛选

验证数据

NM-HU-2000055 hIL2RB.png

图1. RT-PCR检测IL2RB人源化小鼠肝脏中hIL2RB的表达情况。引物对P1/2特异针对511bp的鼠源Il2rb序列,引物对P1/3特异针对513bp的人源IL2RB序列,M:100bp Plus DNA ladder from Transgen (BM311)。

结果表明,杂合子小鼠(HE)肝脏同时表达人源IL2RB和鼠源Il2rb,野生型小鼠(WT)肝脏只表达鼠源Il2rb。


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