hSIGLEC15(BALB/c)

品系全名

BALB/cJSmo-Siglec15tm2(hSIGLEC15) Smoc

目录号

NM-HU-200001

品系状态

胚胎冻存

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基因信息

基因名
SIGLEC15

品系描述

通过同源重组,将小鼠Siglec15基因进行人源化修饰。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

image.png

Fig1. Detection of SIGLEC15 expression by RT-PCR. 

Wild type: only one band at 389 bp with primers F2/R2(mSiglec15);

Homozygous: only one band at 388 bp with primers F1/R1(hSIGLEC15); 

Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.


image.png

图1.流式检测SIGLEC15人源化小鼠巨噬细胞上hSIGLEC15的表达情况。结果显示,纯合子小鼠腹腔巨噬细胞中可以检测到hSIGLEC15的表达,骨髓巨噬细胞中检测不到hSIGLEC15的明显表达。


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