hVEGFR2
品系全名
C57BL/6JSmo-Kdrtm2(hKDR) Smoc
目录号
NM-HU-00098
品系状态
胚胎冻存
基因信息
基因名
KDR
品系描述
验证数据
Fig1. Detection of KDR expression by RT-PCR.
Wild type: only one band at 414 bp with primers 1/2(mKdr);
Heterozygous: one band at 414 bp with primers 1/2(mKDR) and one band at 414 bp with primers 3/4(hKDR);
Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
图2:人源化KDR纯合子(huKDR-HO)小鼠中鼠源KDR蛋白和人源KDR蛋白的表达。结果显示huKDR-HO小鼠表达高水平的人源KDR蛋白，不表达鼠源KDR蛋白，符合预期。
图3 ：KDR人源化小鼠 B16F1 荷瘤模型体内抗肿瘤药效验证。结果显示： 针对人源KDR的药物(CYRAMZA 即ramucirumab，雷莫芦单抗)有非常显著的抗肿瘤效果，证明 KDR人源化小鼠是一个很好的验证针对人 KDR药物药效的体内模型。
图4 ：KDR人源化小鼠 MC38 荷瘤模型体内抗肿瘤药效剂量验证。结果显示： 针对人源KDR 的药物(ramucirumab 即CYRAMZA，雷莫芦单抗)有非常显著的抗肿瘤效果。
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