hICOS

品系全名

C57BL/6JSmo-Icostm1(hICOS)Smoc

目录号

NM-HU-00052

品系状态

活体

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基因信息

基因名
ICOS

品系描述

通过同源重组,将小鼠基因Icos进行人源化修饰。与此相似的品系还有hICOS(2)(NM-HU-190030),详细信息请咨询技术顾问。
应用领域:免疫治疗;肿瘤研究;药物筛选

验证数据

  • ICOS人源化小鼠流式分析(FACS)数据

image.png

图1.  ICOS 人源化小鼠脾脏淋巴细胞活化后 FACS 检测 ICOS 表达。ICOS 人源化杂合子小鼠脾脏淋巴细胞经 anti-CD3 和 anti-CD28 刺激 48h 后收集细胞染色,同时设立不刺激组,抗体染色后,FACS检测人源 ICOS 表达。结果显示:ICOS 人源化杂合子小鼠活化的CD4+和 CD8+T 淋巴细胞中可以检测到人源 ICOS 的活跃表达。



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