hIL21R

品系全名

C57BL/6JSmo-Il21rtm1(hIL21R)Smoc

目录号

NM-HU-210031

品系状态

胚胎冻存

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基因信息

基因名
IL21R

品系描述

利用ES细胞打靶方式,将小鼠Il21r基因全部或者部分替换为人源IL21R。从而表达人或人鼠嵌合IL21R蛋白,取代小鼠内源Il21r蛋白的表达。
应用领域:免疫治疗;药物筛选

验证数据

image.png

Fig.1 Detection of IL21R expression in spleen and thymus by RT-PCR in hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).

Wild type: only one band at 189 bp with primers F1/R1(mIl21r);

Homozygous: only one band at 177 bp with primers F2/R2(hIL21R).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of hIL21R expression in activated splenocyte in WT C57BL/6 and HO hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).



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