hCCR8
品系全名
C57BL/6JSmo-Ccr8tm1(hCCR8) Smoc
目录号
NM-HU-190053
品系状态
胚胎冻存
基因信息
基因名
CCR8
品系描述
验证数据
Fig1. 流式检测 CCR8 人源化小鼠血液中各类免疫细胞的比例。
Fig2. 流式检测 CCR8 人源化小鼠脾脏中免疫细胞的总比例。
Fig3. 流式检测 CCR8 人源化小鼠中 CCR8 的表达。
Fig4. 流式检测 CCR8 人源化小鼠的 T 细胞与 CCR8 抗体药物的结合效率。
图5. hCCR8抗体（anti-hCCR8）可以抑制CCR8人源化小鼠上MC38-OVA移植瘤的生长和浸润。(A)给药方案示意图； (B) 平均肿瘤体积和个体肿瘤体积； (C) anti-hCCR8治疗后肿瘤浸润 CCR8+ Treg细胞的情况（蓝绿色为对照组，黄色为anti-hCCR8治疗组）。（与Crownbio合作完成）
图6. hCCR8抗体（anti-hCCR8）可以抑制CCR8人源化小鼠上Hepa1-6移植瘤的生长和浸润。(A)给药方案示意图； (B) 平均肿瘤体积和个体肿瘤体积； (C) anti-hCCR8治疗后肿瘤浸润 CCR8+ Treg细胞的情况（蓝绿色为对照组，黄色为anti-hCCR8治疗组）。（与Crownbio合作完成）
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