hDPP4

品系全名

C57BL/6Smoc-Dpp4tm1(DPP4)Smoc

目录号

NM-HU-190042

品系状态

活体

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基因信息

基因名
Dpp4

基因曾用名

Cd26; THAM; Dpp-4

NCBI ID

13482

MGI ID

94919

Ensembl ID

ENSMUSG00000035000

Pubmed

Dpp4

人类同源基因

DPP4

品系描述

通过同源重组，将小鼠Dpp4基因进行人源化修饰。
应用领域：用于MERS感染研究

验证数据

image.png

Fig1. Detection of hDPP4 (CD26) expression in HO hDPP4 KI mice by FACS. 

image.png

Fig2. Detection of human DPP4 (A) and mouse DPP4 (B) expression in plasma by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

发表文献

Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice
来源杂志：Nature Communications

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