模型资源
- 成品模型
- 工具小鼠
- Find Cre 工具鼠
- 报告基因工具鼠
- 荧光示踪小鼠
- 其他报告基因工具鼠
- 基因调控工具鼠
- 四环素调控工具鼠
- 疾病小鼠(U-DMbase®)
- 自发肿瘤小鼠模型
- 罕见病小鼠模型
- 传染病研究模型
- 神经系统疾病模型
- 代谢心血管疾病模型
- 自身免疫疾病模型
- 免疫学研究小鼠
- 免疫靶点人源化小鼠
- 免疫缺陷小鼠
- 免疫细胞标记小鼠
- 细胞因子示踪小鼠
- 免疫细胞剔除小鼠
- 人源化小鼠
- 肿瘤靶点
- 免疫检查点
- 补体系统靶点
- 细胞因子
- 细胞因子受体
- 代谢靶点
- 病毒感染受体
- 其他靶点
- 常规基因修饰模型
- 全身敲除小鼠
- 条件性敲除小鼠
- 过表达小鼠
- 点突变小鼠
- 敲入小鼠
- 大鼠模型资源库
- 免疫缺陷大鼠
- 人源化大鼠
- 荧光示踪大鼠
- 疾病模型
- 工具大鼠
- 细胞系
- 其他细胞系
- 原代细胞系
- 人源化细胞系
- 荧光细胞系
- 野生型细胞系
- 常规小鼠品系
- 远交系(封闭群)小鼠
- 近交系小鼠
M-NSG
品系全名
NOD.Cg-PrkdcscidIl2rgem1Smoc
目录号
NM-NSG-001
品系状态
活体
基因信息
基因名
IL2RG
基因曾用名
gc; p64; [g]c; CD132; gamma(c)
NCBI ID
MGI ID
Ensembl ID
Pubmed
人类同源基因
IL2RG
品系描述
验证数据
表型分析
M-NSG小鼠生长曲线

图1. M-NSG小鼠生长曲线(n=600)
T、B、NK 细胞 FACS 检测

图 2.M-NSG 小鼠脾脏(A)与外周血(B)中 T、B 和 NK 细胞缺失。取 BALB/c、M-NSG 小鼠的脾脏细胞与外周血,通过 FACS 对其中 T、B 和 NK 细胞的组成进行分析并进行统计对比。
M、MΦ、DC 细胞 FACS 检测

图 3.M-NSG 小鼠脾脏(A)与外周血(B)中 单核细胞、巨噬细胞和 DC 细胞比例。取 BALB/c、M-NSG 小鼠的脾脏细胞与外周血,通过 FACS 对其中单核细胞、巨噬细胞和 DC 细胞的组成进行分析并进行统计对比。
血清抗体亚类检测

图4. M-NSG小鼠血清抗体亚类检测(雄性,8周龄)。
各组织病理学检测

图5. M-NSG 各组织病理学检测。A:除脾脏和胸腺外,其他组织未见明显异常,包括:脑、视网膜、脊髓、心脏、肝、肺、肾、小肠、大肠、胃、唾液腺、胰腺、卵巢、子宫、睾丸、附睾、骨骼肌、皮肤和棕色脂肪(雌性,6周龄);
M-NSG小鼠血常规检测

M-NSG小鼠血生化检测

CDX/PDX成瘤及药效验证

图8. A549 肺肿瘤细胞(A)或 Raji 淋巴瘤细胞(B)在 M-NSG 小鼠上的成瘤验证。
基于 M-NSG 小鼠成功建立的 CDX 模型

图9.利用淋巴癌(Raji)CDX模型进行抗人CD47抗体药效验证实验。

图10. 利用肺癌(A549)CDX模型进行CAR-T药效验证实验。

图11. 移植CAR-T的M-NSG小鼠体内的GVHD研究。

图12. 肝癌PDX在 M-NSG 小鼠上的成瘤验证。
人源免疫系统重建模型
利用重度免疫缺陷M-NSG小鼠可以通过移植人源外周血细胞、造血干细胞等,实现在小鼠体内重塑人源免疫系统,为免疫学、肿瘤学及人类传染疾病等研究提供有力工具。
PBMC人源化小鼠

Hu-PBMC模型,或者被称为Hu-PBL(perihperal blood lymphocyte, PBL)模型,是一种构建较为简单和经济的免疫系统人源化小鼠模型。Hu-PBMC模型的移植方式主要有腹腔注射与尾静脉注射,通常以4-6周龄的M-NSG小鼠作为移植受体,PBMC移植/接种量通常在5~10*10^6/小鼠。该模型常被用于研究人效应T细胞的活化以及评估免疫抑制药物。
Hu-PBMC模型的供体筛选

图13. M-NSG小鼠中进行Hu-PBMC重建的供体筛选。
图14.流式分析Hu-PBMC模型外周血淋巴细胞亚群。将人PBMCs(5E6)静脉注射M-NSG小鼠(雌性,6-8周龄,n=4)。植入human PBMCs后取不同时间点的小鼠血液进行流式细胞分析。
图15. 利用骨髓瘤(H929)Hu-PBMC模型进行体内药效研究。

图16. 利用乳腺癌(MDA-MB-231)Hu-PBMC模型进行体内药效研究。
HSC人源化小鼠

Hu-HSC模型,也叫hu-CD34+,或叫hu-SRC(scid-repopulatingcell),已经被广泛应用于研究人类造血发育、细胞介导的免疫反应以及HIV和EBV等病毒感染性疾病中。 其构建方式是将来自人脐带血、骨髓、G-CSF激活的外周血或胎肝的人CD34+ HSCs通过静脉内(i.v.)或股骨内(i.f.)注射到成年免疫缺陷小鼠M-NSG中,得到的小鼠可以产生多种造血干细胞。
图17. M-NSG小鼠中进行Hu-HSC重建的供体筛选。

图18. 流式分析Hu-HSC模型外周血淋巴细胞亚群。

图19. 利用乳腺癌(MDA-MB-231)Hu-HSC模型进行体内药效研究。
发表文献 292篇
1.
Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
发表年份:2026
来源杂志:Nature Aging
2.
FOSL1 Orchestrates Epigenetic Reprogramming of Anaplastic Thyroid Cancer and Suppresses Natural Killer Cell-Mediated Antitumor Immunity
发表年份:2026
来源杂志:CANCER RESEARCH
3.
Structure–Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia
发表年份:2026
来源杂志:Journal of the American Chemical Society
4.
Apoptotic bodies derived from human umbilical cord mesenchymal stem cells improve recovery from myocardial infarction in swine
发表年份:2026
来源杂志:Autophagy
5.
ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC-I Antigen Presentation That Promotes Tumor Immune Evasion
发表年份:2026
来源杂志:Advanced Science
6.
PD-L1-Binding Antigen Presenters: Redirecting Vaccine-Induced Antibodies for Cancer Immunotherapy
发表年份:2026
来源杂志:Advanced Science
7.
Vessels encapsulating tumor clusters promote non-invasive metastasis of hepatocellular carcinoma by shaping an immunosuppressive microenvironment
发表年份:2026
来源杂志:JOURNAL OF CLINICAL INVESTIGATION
8.
Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors
发表年份:2026
来源杂志:Science Advances
9.
mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
发表年份:2026
来源杂志:Cell Reports Medicine
10.
Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy
发表年份:2026
来源杂志:Journal for ImmunoTherapy of Cancer
11.
A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
发表年份:2026
来源杂志:Cell Reports Medicine
12.
Targeting FGFR1-regulated SPP1 signaling repolarizes immunosuppressive macrophages and sensitizes Hepatocellular Carcinoma to anti-PD-1 therapy
发表年份:2026
来源杂志:CANCER LETTERS
13.
USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination
发表年份:2026
来源杂志:International Journal of Biological Sciences
14.
Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy
发表年份:2026
来源杂志:DEVELOPMENTAL CELL
15.
A shark VNAR-IL-15 fusion protein that suppresses TROP2+ tumor growth
发表年份:2026
来源杂志:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
16.
Silencing SFRP1 in bone mesenchymal stem cells alleviates pediatric B-ALL-driven bone loss by activating Wnt/β-catenin signaling
发表年份:2026
来源杂志:Journal of Orthopaedic Translation
17.
Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC class I-deficient solid tumors
发表年份:2026
来源杂志:Cell Reports
18.
Discovery of Oxime Ether Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer
发表年份:2026
来源杂志:JOURNAL OF MEDICINAL CHEMISTRY
19.
Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia
发表年份:2026
来源杂志:Chinese Medicine
20.
Lycorine suppresses cell growth and attenuates stemness through PI3K/AKT pathway in ovarian cancer
发表年份:2026
来源杂志:BIOCHEMICAL PHARMACOLOGY
21.
Multi-omics classification of acute myeloid leukemia guides drug combinations to overcome Venetoclax resistance
发表年份:2026
来源杂志:Cancer Drug Resistance
22.
ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications
发表年份:2026
来源杂志:LIFE SCIENCES
23.
A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice
发表年份:2026
来源杂志:Scientific Reports
24.
Preclinical Evaluation of AHT-102, a CLDN18.2 × CD3 Bispecific Antibody: Pharmacokinetics, Anti-Tumor Efficacy, Tissue Distribution, and Safety Profile
发表年份:2026
来源杂志:DRUGS IN R&D
25.
Construction of a novel B7H3 VHH-Fc antibody with potent antitumor activity and NK/T cell activation
发表年份:2026
来源杂志:PROTEIN EXPRESSION AND PURIFICATION
26.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
发表年份:2025
来源杂志:NATURE
27.
SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target
发表年份:2025
来源杂志:Cellular & Molecular Immunology
28.
TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis
发表年份:2025
来源杂志:CANCER RESEARCH
29.
MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer
发表年份:2025
来源杂志:CANCER RESEARCH
30.
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
发表年份:2025
来源杂志:Nature Communications
31.
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination
发表年份:2025
来源杂志:Acta Pharmaceutica Sinica B
32.
OX40–heparan sulfate binding facilitates CAR T cell penetration into solid tumors in mice
发表年份:2025
来源杂志:Science Translational Medicine
33.
Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant Glioma
发表年份:2025
来源杂志:Advanced Science
34.
Chemotherapy-Mediated Induction of PD-L1 via SEI1 Facilitates Myeloma Immune Evasion
发表年份:2025
来源杂志:Advanced Science
35.
DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR-JAK2-STAT3 Pathway
发表年份:2025
来源杂志:Advanced Science
36.
SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
发表年份:2025
来源杂志:Advanced Science
37.
An Engineered Probiotic Consortium Based on Quorum-Sensing for Colorectal Cancer Immunotherapy
发表年份:2025
来源杂志:Advanced Science
38.
SIRT5 inhibition impairs mitochondrial metabolism and enhances venetoclax-induced elimination of acute myeloid leukemia cells
发表年份:2025
来源杂志:LEUKEMIA
39.
Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2
发表年份:2025
来源杂志:LEUKEMIA
40.
STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells
发表年份:2025
来源杂志:LEUKEMIA
41.
5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia
发表年份:2025
来源杂志:JOURNAL OF NANOBIOTECHNOLOGY
42.
Asparaginase Enhances CAR-T Cell Antitumor Immunity by Asparagine Metabolic Reprogramming and Induction of Central Memory Phenotype in ALL
发表年份:2025
来源杂志:MOLECULAR THERAPY
43.
BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancer
发表年份:2025
来源杂志:Journal for ImmunoTherapy of Cancer
44.
JMJD3 upregulates ALOX5 to drive malignancy and concomitant ferroptosis sensitivity in gastric cancer
发表年份:2025
来源杂志:Cell Death & Disease
45.
Low SVEP1 in intrahepatic cholangiocarcinoma mediates phenotype switching-driven metastasis by Jag2/Notch1/Hes5
发表年份:2025
来源杂志:Cell Death & Disease
46.
UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia
发表年份:2025
来源杂志:Cell Death & Disease
47.
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation
发表年份:2025
来源杂志:Cell Death & Disease
48.
Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma
发表年份:2025
来源杂志:Cell Death & Disease
49.
Tryptamine-Functionalized Lipid Nanocarriers Co-delivering SMO/BRD4 Inhibitors for Synergistic Medulloblastoma Therapy
发表年份:2025
来源杂志:Biomaterials Research
50.
Ephrin A1 functions as a ligand of EGFR to promote EMT and metastasis in gastric cancer
发表年份:2025
来源杂志:EMBO JOURNAL
51.
Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model
发表年份:2025
来源杂志:Cell Communication and Signaling
52.
Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion
发表年份:2025
来源杂志:Cell Communication and Signaling
53.
Histone acetylation activated-IGF2BP3 regulates cyclin D1 mRNA stability to drive cell cycle transition and tumor progression of hepatocellular carcinoma
发表年份:2025
来源杂志:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
54.
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe
发表年份:2025
来源杂志:PHYTOMEDICINE
55.
CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis
发表年份:2025
来源杂志:PHYTOMEDICINE
56.
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma
发表年份:2025
来源杂志:npj Precision Oncology
57.
Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer
发表年份:2025
来源杂志:NEOPLASIA
58.
T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus
发表年份:2025
来源杂志:Journal of Translational Medicine
59.
Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer
发表年份:2025
来源杂志:Cell Reports
60.
LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy
发表年份:2025
来源杂志:ONCOGENE
61.
KRT5high TP63-expressing urothelial basal cells act as a driver to bladder urothelium regeneration in rabbit
发表年份:2025
来源杂志:Stem Cell Research & Therapy
62.
Metrnl protects intestinal barrier function by regulating tight junctions via the IKKβ/IκBα/NFκB/MLCK/MLC signaling pathway
发表年份:2025
来源杂志:Cell Death Discovery
63.
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy
发表年份:2025
来源杂志:Cell Reports
64.
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA
发表年份:2025
来源杂志:Cell Reports
65.
Discovery of P11–2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer
发表年份:2025
来源杂志:JOURNAL OF MEDICINAL CHEMISTRY
66.
Deciphering the role of IGF2BP2 and PRMT5 in gallbladder cancer progression: insights from multi-omics analysis
发表年份:2025
来源杂志:BRITISH JOURNAL OF CANCER
67.
The pronounced cytotoxic effects of chimeric antigen receptor T cells targeting B7-H3 in organoids and liver xenografts derived from colorectal cancer patients
发表年份:2025
来源杂志:BRITISH JOURNAL OF CANCER
68.
Tumor-derived CD84 promotes growth of acute myeloid leukemia cells via regulating non-homologous DNA end joining pathway
发表年份:2025
来源杂志:MOLECULES AND CELLS
69.
Coke Oven Emission Exposure Triggers Malignant Transformation of Lung Epithelial Cells by SFTA1P-Dependent Alteration of Acetyl-CoA Metabolism
发表年份:2025
来源杂志:Environment & Health
70.
Targeted editing of CCL5 with CRISPR-Cas9 nanoparticles enhances breast cancer immunotherapy
发表年份:2025
来源杂志:APOPTOSIS
71.
COL4A2 drives ECM remodeling and stiffness increasing to promote breast cancer metastasis via YAP signaling pathway in dECM induced models
发表年份:2025
来源杂志:Biomaterials Advances
72.
Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways
发表年份:2025
来源杂志:Cancer Cell International
73.
Chemical induction of ferroptosis through GPX4 inhibition: Rational Design of Triazole-Benzoxazine Hybrids for melanoma therapy
发表年份:2025
来源杂志:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
74.
Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer
发表年份:2025
来源杂志:Frontiers in Immunology
75.
High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer
发表年份:2025
来源杂志:Frontiers in Immunology
76.
Scalable Matrigel-Free Suspension Culture for Generating High-Quality Human Liver Ductal Organoids
发表年份:2025
来源杂志:CELL PROLIFERATION
77.
Preclinical Development and a Case Report of a Nanobody-Based CLDN18.2 CAR-T IMC002 with Reduced On-Target Off-Tumor Toxicity
发表年份:2025
来源杂志:MOLECULAR CANCER THERAPEUTICS
78.
Optimization of a Novel 2 + 2 BCMA × CD3 Bispecific Antibody for Minimized Cytokine Release and Potent Efficacy
发表年份:2025
来源杂志:MOLECULAR CANCER THERAPEUTICS
79.
Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer
发表年份:2025
来源杂志:CELL BIOLOGY AND TOXICOLOGY
80.
Targeted delivery of circPDHK1 siRNA via aptamer functionalized lipid nanoparticles inhibits ccRCC growth and migration
发表年份:2025
来源杂志:INTERNATIONAL JOURNAL OF PHARMACEUTICS
81.
mRNA-laden lipid nanoparticle-enabled humanized CD19 CAR-T-cell engineering for the eradication of leukaemic cells
发表年份:2025
来源杂志:BRITISH JOURNAL OF HAEMATOLOGY
82.
In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China
发表年份:2025
来源杂志:Frontiers in Cellular and Infection Microbiology
83.
Cbl-b inhibition improves manufacturing efficiency and antitumoral efficacy of anti-CD19 CAR-T cells
发表年份:2025
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
84.
ASF1B promotes gastric cancer progression by modulating H2AC20 and activating PI3K/AKT and ERK1/2 pathways
发表年份:2025
来源杂志:Frontiers in Pharmacology
85.
NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia
发表年份:2025
来源杂志:CANCER BIOLOGY & THERAPY
86.
Motor neuron and pancreas homeobox 1 (MNX1) suppresses Triple Negative Breast Cancer (TNBC) cell phagocytosis by macrophage through CD24 signaling
发表年份:2025
来源杂志:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
87.
CD9 antibody enhances the anti-leukemia efficacy of γδT cells in adult B cell acute lymphoblastic leukemia
发表年份:2025
来源杂志:iScience
88.
Demethylzeylasteral alleviates myeloid leukemia through PERK/eIF2α/ATF4/CHOP-mediated cell apoptosis
发表年份:2025
来源杂志:Translational Cancer Research
89.
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy
发表年份:2025
来源杂志:Signal Transduction and Targeted Therapy
90.
A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer
发表年份:2025
来源杂志:Nature Nanotechnology
91.
CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA
发表年份:2025
来源杂志:Molecular Cancer
92.
Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming
发表年份:2025
来源杂志:Cell Metabolism
93.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation
发表年份:2025
来源杂志:Cell Metabolism
94.
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses
发表年份:2025
来源杂志:Nature Biomedical Engineering
95.
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
发表年份:2025
来源杂志:IMMUNITY
96.
Clinical functional proteomics of intercellular signalling in pancreatic cancer
发表年份:2024
来源杂志:NATURE
97.
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
发表年份:2024
来源杂志:CANCER CELL
98.
Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
发表年份:2024
来源杂志:NATURE MATERIALS
99.
An oncolytic virus–T cell chimera for cancer immunotherapy
发表年份:2024
来源杂志:NATURE BIOTECHNOLOGY
100.
The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma
发表年份:2024
来源杂志:Cancer Discovery
101.
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
发表年份:2024
来源杂志:Cell Metabolism
102.
Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
发表年份:2024
来源杂志:Cell Metabolism
103.
A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway
发表年份:2024
来源杂志:Molecular Cancer
104.
Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors
发表年份:2024
来源杂志:ADVANCED MATERIALS
105.
An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity
发表年份:2024
来源杂志:ADVANCED MATERIALS
106.
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone
发表年份:2024
来源杂志:Nature Biomedical Engineering
107.
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
发表年份:2024
来源杂志:Cell Stem Cell
108.
FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
发表年份:2024
来源杂志:Nature Communications
109.
Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
发表年份:2024
来源杂志:Nature Communications
110.
PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
发表年份:2024
来源杂志:Nature Communications
111.
Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy
发表年份:2024
来源杂志:Nature Communications
112.
Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice
发表年份:2024
来源杂志:Nature Communications
113.
Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity
发表年份:2024
来源杂志:Nature Communications
114.
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
发表年份:2024
来源杂志:Nature Communications
115.
Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies
发表年份:2024
来源杂志:Nature Communications
116.
ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms
发表年份:2024
来源杂志:Autophagy
117.
Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis
发表年份:2024
来源杂志:Advanced Science
118.
Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development
发表年份:2024
来源杂志:Advanced Science
119.
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer
发表年份:2024
来源杂志:Advanced Science
120.
SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis
发表年份:2024
来源杂志:Advanced Science
121.
A pan-KRAS degrader for the treatment of KRAS-mutant cancers
发表年份:2024
来源杂志:Cell Discovery
122.
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
发表年份:2024
来源杂志:LEUKEMIA
123.
Anagrelide and idarubicin combination induces GSDME-mediated pyroptosis as a potential therapy for high-PDE3A acute myeloid leukemia
发表年份:2024
来源杂志:LEUKEMIA
124.
Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
发表年份:2024
来源杂志:CANCER RESEARCH
125.
Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma
发表年份:2024
来源杂志:CANCER RESEARCH
126.
Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia
发表年份:2024
来源杂志:CANCER RESEARCH
127.
PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression
发表年份:2024
来源杂志:CANCER RESEARCH
128.
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
发表年份:2024
来源杂志:Theranostics
129.
Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease
发表年份:2024
来源杂志:Gut Microbes
130.
Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia
发表年份:2024
来源杂志:Cell Reports Medicine
131.
Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
132.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia
发表年份:2024
来源杂志:Journal of Advanced Research
133.
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies
发表年份:2024
来源杂志:Journal of Advanced Research
134.
Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
135.
LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
136.
USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERα
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
137.
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation
发表年份:2024
来源杂志:MedComm
138.
Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy
发表年份:2024
来源杂志:JOURNAL OF NANOBIOTECHNOLOGY
139.
RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
140.
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
141.
ImmunoPET imaging of LAG-3 expression in tumor microenvironment with 68Ga-labelled cyclic peptides tracers: from bench to bedside
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
142.
Engineered oncolytic virus expressing B7H3-targeting BiTE enhances antitumor T-cell immune response
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
143.
Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
发表年份:2024
来源杂志:EMBO JOURNAL
144.
Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
发表年份:2024
来源杂志:Cell Communication and Signaling
145.
KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis
发表年份:2024
来源杂志:International Journal of Biological Sciences
146.
The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
发表年份:2024
来源杂志:Cell Death & Disease
147.
A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
发表年份:2024
来源杂志:Cell Death & Disease
148.
EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification
发表年份:2024
来源杂志:JOURNAL OF AUTOIMMUNITY
149.
Connexin 25 maintains self-renewal and functions of airway basal cells for airway regeneration
发表年份:2024
来源杂志:Stem Cell Research & Therapy
150.
Human umbilical cord mesenchymal stem cell-based gene therapy for hemophilia B using scAAV-DJ/8-LP1-hFIXco transduction
发表年份:2024
来源杂志:Stem Cell Research & Therapy
151.
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer
发表年份:2024
来源杂志:BIOMEDICINE & PHARMACOTHERAPY
152.
IGSF9 promotes tumor invasion and metastasis through GSK-3β/β-catenin mediated EMT in lung cancer
发表年份:2024
来源杂志:NEOPLASIA
153.
TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway
发表年份:2024
来源杂志:Journal of Translational Medicine
154.
IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer
发表年份:2024
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
155.
Oncolytic virus encoding 4-1BBL and IL15 enhances the efficacy of tumor-infiltrating lymphocyte adoptive therapy in HCC
发表年份:2024
来源杂志:CANCER GENE THERAPY
156.
ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer
发表年份:2024
来源杂志:Translational Oncology
157.
Effective in vivo reactivation of HIV-1 latency reservoir via oral administration of EK-16A-SNEDDS
发表年份:2024
来源杂志:EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
158.
Single-cell RNA-sequencing reveals a profound immune cell response in human cytomegalovirus-infected humanized mice
发表年份:2024
来源杂志:VIROLOGICA SINICA
159.
Generation of self-renewing neuromesodermal progenitors with neuronal and skeletal muscle bipotential from human embryonic stem cells
发表年份:2024
来源杂志:Cell Reports Methods
160.
PLA2G2D promotes immune escape in non-small cell lung cancer by regulating T cell immune function through PD-L1-expressing extracellular vesicles
发表年份:2024
来源杂志:SCANDINAVIAN JOURNAL OF IMMUNOLOGY
161.
Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer
发表年份:2024
来源杂志:Biomedicines
162.
Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity
发表年份:2024
来源杂志:ACS Omega
163.
FYB1-targeted modulation of CAPG promotes AML progression
发表年份:2024
来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY
164.
The DHODH inhibitor teriflunomide impedes cell proliferation and enhances chemosensitivity to daunorubicin (DNR) in T-cell acute lymphoblastic leukemia
发表年份:2024
来源杂志:ANNALS OF HEMATOLOGY
165.
PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome
发表年份:2024
来源杂志:DNA AND CELL BIOLOGY
166.
Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice
发表年份:2024
来源杂志:Journal of Gastrointestinal Oncology
167.
Restoring T and B cell generation in X-linked severe combined immunodeficiency mice through hematopoietic stem cells adenine base editing
发表年份:2024
来源杂志:MOLECULAR THERAPY
168.
Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification
发表年份:2024
来源杂志:PHARMACOLOGICAL RESEARCH
169.
miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair
发表年份:2024
来源杂志:JACC-Basic to Translational Science
170.
Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis
发表年份:2024
来源杂志:International Journal of Biological Sciences
171.
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma
发表年份:2024
来源杂志:Cell Death & Disease
172.
Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation
发表年份:2024
来源杂志:Cell Death & Disease
173.
Small extracellular vesicle piR-hsa-30937 derived from pancreatic neuroendocrine neoplasms upregulates CD276 in macrophages to promote immune evasion
发表年份:2024
来源杂志:Cancer Immunology Research
174.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
发表年份:2024
来源杂志:Cell Reports
175.
Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation
发表年份:2024
来源杂志:Stem Cell Research & Therapy
176.
Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation
发表年份:2024
来源杂志:PHYTOMEDICINE
177.
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
发表年份:2024
来源杂志:OncoImmunology
178.
PHE1-based IgG-like antibody platform provides a novel strategy for enhanced T-cell immunotherapy
发表年份:2024
来源杂志:Frontiers in Immunology
179.
INPP4B suppresses HER2-induced mesenchymal transition in HER2+ breast cancer and enhances sensitivity to Lapatinib
发表年份:2024
来源杂志:BIOCHEMICAL PHARMACOLOGY
180.
The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
发表年份:2024
来源杂志:MOLECULAR CANCER THERAPEUTICS
181.
TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B-cell lymphomas
发表年份:2024
来源杂志:LIFE SCIENCES
182.
FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis
发表年份:2024
来源杂志:Communications Biology
183.
HDAC inhibitors target IRS4 to enhance anti‑AR therapy in AR‑positive triple‑negative breast cancer
发表年份:2024
来源杂志:INTERNATIONAL JOURNAL OF ONCOLOGY
184.
Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model
发表年份:2024
来源杂志:EJNMMI Radiopharmacy and Chemistry
185.
PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome
发表年份:2024
来源杂志:DNA AND CELL BIOLOGY
186.
Exosome-derived circCCAR1 promotes CD8+T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023-03-18
来源杂志:Molecular Cancer
187.
A novel antidiuretic hormone governs tumour-induced renal dysfunction
发表年份:2023
来源杂志:NATURE
188.
Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals
发表年份:2023
来源杂志:CELL
189.
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
发表年份:2023
来源杂志:Signal Transduction and Targeted Therapy
190.
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023
来源杂志:Molecular Cancer
191.
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
发表年份:2023
来源杂志:NATURE IMMUNOLOGY
192.
Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress
发表年份:2023
来源杂志:GASTROENTEROLOGY
193.
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain
发表年份:2023
来源杂志:Cell Metabolism
194.
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
发表年份:2023
来源杂志:Cellular & Molecular Immunology
195.
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
发表年份:2023
来源杂志:NATURE CELL BIOLOGY
196.
Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells
发表年份:2023
来源杂志:Nature Communications
197.
SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
发表年份:2023
来源杂志:Nature Communications
198.
Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
发表年份:2023
来源杂志:Nature Communications
199.
Sequence-based drug design as a concept in computational drug design
发表年份:2023
来源杂志:Nature Communications
200.
TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
发表年份:2023
来源杂志:Nature Communications
201.
Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors
发表年份:2023
来源杂志:Cancer Communications
202.
Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins
发表年份:2023
来源杂志:Cancer Communications
203.
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling
发表年份:2023
来源杂志:JOURNAL OF CLINICAL INVESTIGATION
204.
Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s
发表年份:2023
来源杂志:JOURNAL OF EXPERIMENTAL MEDICINE
205.
CAR-Aptamers Enable Traceless Enrichment and Monitoring of CAR-Positive Cells and Overcome Tumor Immune Escape
发表年份:2023
来源杂志:Advanced Science
206.
NIRF/PET imaging of γδ T cells via metabolic glycoengineering and bioorthogonal labeling
发表年份:2023
来源杂志:CHEMICAL ENGINEERING JOURNAL
207.
Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA-Seq
发表年份:2023
来源杂志:Advanced Science
208.
Targeted therapy of central nervous system acute lymphoblastic leukemia with an integrin α6-targeted self-assembling proapoptotic nanopeptide
发表年份:2023
来源杂志:Engineering
209.
Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis
发表年份:2023
来源杂志:Gut Microbes
210.
Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
发表年份:2023
来源杂志:LEUKEMIA
211.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
发表年份:2023
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
212.
Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
发表年份:2023
来源杂志:CANCER RESEARCH
213.
PICH activates Cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer.
发表年份:2023
来源杂志:CANCER RESEARCH
214.
Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA-4 and PD-1 checkpoint blockade
发表年份:2023
来源杂志:CANCER RESEARCH
215.
Targeted glycan degradation potentiates cellular immunotherapy for solid tumors
发表年份:2023
来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
216.
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia
发表年份:2023
来源杂志:Biomarker Research
217.
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
发表年份:2023
来源杂志:JOURNAL OF NANOBIOTECHNOLOGY
218.
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response
发表年份:2023
来源杂志:HAEMATOLOGICA
219.
Tissue factor overexpression in triple-negative breast cancer promotes immune evasion by impeding T-cell infiltration and effector function
发表年份:2023
来源杂志:CANCER LETTERS
220.
Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia
发表年份:2023
来源杂志:PHARMACOLOGICAL RESEARCH
221.
PARP inhibitor exerts an anti-tumor effect via LMO2 and synergizes with cisplatin in natural killer/T cell lymphoma
发表年份:2023
来源杂志:BMC Medicine
222.
Alternative splicing of HOXB-AS3 underlie the promoting effect of nuclear m6A reader YTHDC1 on the self-renewal of leukemic stem cells in acute myeloid leukemia
发表年份:2023
来源杂志:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
223.
TGF-β blocking combined with photothermal therapy promote tumor targeted migration and long-term antitumor activity of CAR-T cells
发表年份:2023
来源杂志:Materials Today Bio
224.
Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities
发表年份:2023
来源杂志:ACTA PHARMACOLOGICA SINICA
225.
Hypoimmunogenic human pluripotent stem cells are valid cell sources for cell therapeutics with normal self-renewal and multilineage differentiation capacity
发表年份:2023
来源杂志:Stem Cell Research & Therapy
226.
Bispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager
发表年份:2023
来源杂志:Frontiers in Immunology
227.
SIGLEC10+ macrophages drive gastric cancer progression by suppressing CD8+ T cell function
发表年份:2023
来源杂志:CANCER IMMUNOLOGY IMMUNOTHERAPY
228.
Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma
发表年份:2023
来源杂志:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
229.
CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing
发表年份:2023
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
230.
Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo
发表年份:2023
来源杂志:VIROLOGICA SINICA
231.
Bruton tyrosine kinase inhibitors preserve anti-CD19 chimeric antigen receptor T-cell functionality and reprogram tumor micro-environment in B-cell lymphoma
发表年份:2023
来源杂志:CYTOTHERAPY
232.
A second-generation CD38-CAR-T cell for the treatment of multiple myeloma
发表年份:2023
来源杂志:Cancer Medicine
233.
Oxymatrine boosts hematopoietic regeneration by modulating MAPK/ERK phosphorylation after irradiation-induced hematopoietic injury
发表年份:2023
来源杂志:EXPERIMENTAL CELL RESEARCH
234.
PD-L1 ImmunoPET on the basis of Avidin/Biotin pre-targeted cancer imaging
发表年份:2023
来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
235.
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022-07-26
来源杂志:nature communications
236.
A Chimeric Conjugate of Antibody and Programmable DNA Nanoassembly Smartly Activates T cell for Precise Cancer Cell Targeting
发表年份:2022-06-24
来源杂志:A Journal of the Gesellschaft Deutscher Chemiker
237.
BSA-AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma
发表年份:2022
来源杂志:ADVANCED MATERIALS
238.
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy
发表年份:2022
来源杂志:Nature Biomedical Engineering
239.
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022
来源杂志:Nature Communications
240.
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica
发表年份:2022
来源杂志:Nature Communications
241.
Modeling Human Thyroid Development by Fetal Tissue-Derived Organoid Culture
发表年份:2022
来源杂志:Advanced Science
242.
Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti-Leukemia Efficacy of CAR-T Cells via SOCE-Calcineurin-NFAT and Glycolysis Pathways
发表年份:2022
来源杂志:Advanced Science
243.
Nano-Biohybrid DNA Engager That Reprograms the T-Cell Receptor
发表年份:2022
来源杂志:Journal of the American Chemical Society
244.
Therapeutic strategies targeting uPAR potentiate anti–PD-1 efficacy in diffuse-type gastric cancer
发表年份:2022
来源杂志:Science Advances
245.
Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia
发表年份:2022
来源杂志:Acta Pharmaceutica Sinica B
246.
An armed oncolytic virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen-presenting cells in situ
发表年份:2022
来源杂志:MOLECULAR THERAPY
247.
Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction
发表年份:2022
来源杂志:LEUKEMIA
248.
FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
发表年份:2022
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
249.
Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL
发表年份:2022
来源杂志:CELL DEATH AND DIFFERENTIATION
250.
Visualizing γδ T cells by very late antigen-4-targeted positron emission tomography
发表年份:2022
来源杂志:EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
251.
Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2
发表年份:2022
来源杂志:Cell Reports
252.
Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations
发表年份:2022
来源杂志:Cell Reports
253.
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma
发表年份:2022
来源杂志:Cell Death & Disease
254.
Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma
发表年份:2022
来源杂志:Cell Death & Disease
255.
LncSIK1 enhanced the sensitivity of AML cells to retinoic acid by the E2F1/autophagy pathway
发表年份:2022
来源杂志:CELL PROLIFERATION
256.
Gene therapy with B-cell maturation antigen/CD3 bispecific antibody encoding plasmid DNA for treating multiple myeloma
发表年份:2022
来源杂志:BRITISH JOURNAL OF HAEMATOLOGY
257.
Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells
发表年份:2022
来源杂志:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
258.
SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
发表年份:2022
来源杂志:Frontiers in Pharmacology
259.
Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin
发表年份:2022
来源杂志:Frontiers in Pharmacology
260.
Large-cohort humanized NPI mice reconstituted with CD34+ hematopoietic stem cells are feasible for evaluating preclinical cancer immunotherapy
发表年份:2022
来源杂志:FASEB JOURNAL
261.
Preclinical Assessment of MEK Inhibitors for Malignant Peripheral Nerve Sheath Tumors Reveals Differences in Efficacy and Adaptive Response
发表年份:2022
来源杂志:Frontiers in Oncology
262.
ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma
发表年份:2022
来源杂志:Frontiers in Oncology
263.
LncRNA SNHG3 enhances BMI1 mRNA stability by binding and regulating c-MYC: Implications for the carcinogenic role of SNHG3 in bladder cancer
发表年份:2022
来源杂志:Cancer Medicine
264.
Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
发表年份:2021
来源杂志:SCIENCE
265.
A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity
发表年份:2021
来源杂志:Science Translational Medicine
266.
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
发表年份:2021
来源杂志:MOLECULAR CELL
267.
CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase
发表年份:2021
来源杂志:HEPATOLOGY
268.
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression
发表年份:2021
来源杂志:CANCER RESEARCH
269.
Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma
发表年份:2021
来源杂志:CLINICAL CANCER RESEARCH
270.
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
发表年份:2021
来源杂志:Acta Pharmaceutica Sinica B
271.
TIGIT-Fc Promotes Antitumor Immunity
发表年份:2021
来源杂志:Cancer Immunology Research
272.
FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53
发表年份:2021
来源杂志:ONCOGENE
273.
Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model
发表年份:2021
来源杂志:Frontiers in Immunology
274.
Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells
发表年份:2021
来源杂志:Stem Cell Research & Therapy
275.
Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection
发表年份:2021
来源杂志:Molecular Therapy-Methods & Clinical Development
276.
Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis
发表年份:2021
来源杂志:Cancers
277.
A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms
发表年份:2021
来源杂志:ACTA PHARMACOLOGICA SINICA
278.
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy
发表年份:2021
来源杂志:Frontiers in Bioengineering and Biotechnology
279.
Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy
发表年份:2021
来源杂志:Frontiers in Pharmacology
280.
RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells
发表年份:2021
来源杂志:Stem Cell Reviews and Reports
281.
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway
发表年份:2021
来源杂志:PHYTOMEDICINE
282.
CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway
发表年份:2021
来源杂志:Nanoscale Research Letters
283.
NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair
发表年份:2021
来源杂志:AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
284.
Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China
发表年份:2021
来源杂志:Annals of Translational Medicine
285.
Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
发表年份:2020
来源杂志:CELL
286.
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
发表年份:2020
来源杂志:Nature Communications
287.
Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane-bound and secreted β2m-HLA-G fusion proteins
发表年份:2020
来源杂志:STEM CELLS
288.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
发表年份:2020
来源杂志:Frontiers in Immunology
289.
Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models
发表年份:2020
来源杂志:Frontiers in Oncology
290.
The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation
发表年份:2020
来源杂志:Aging-US
291.
Lgr5 maintains stemness and regulates cell property in nasopharyngeal carcinoma through Wnt/β-catenin signaling pathway
发表年份:2020
来源杂志:Stem Cell Research
292.
Peptide Self-Assembly Nanoparticles Loaded with Panobinostat to Activate Latent Human Immunodeficiency Virus
发表年份:2019-05-01
来源杂志:J Biomed Nanotechnol
参考文献
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
来源杂志:nature communications
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