M-NSG

品系全名

NOD.Cg-PrkdcscidIl2rgem1Smoc

目录号

NM-NSG-001

品系状态

活体

导出PDF

基因信息

基因名
IL2RG

品系描述

NOD背景下Prkdc纯合突变:Prkdc(protein kinase, DNA-activated, catalytic polypeptide)基因主要编码DNA依赖性蛋白激酶(DNA-PK)的催化亚基,是参与双链DNA断裂修复、免疫球蛋白和T细胞受体可变(V)、多样性(D)、连接(J)区段重组的重要基因。Prkdcscid突变代表严重的联合免疫缺陷,表现为缺失T、B细胞,无法介导细胞和体液免疫,不排斥同种和异种移植。无功能T细胞和B细胞,NK细胞活性低,没有溶血补体活性,骨髓发育缺陷。血清免疫球蛋白(Ig)泄漏率非常低,非常适合同种和异种肿瘤移植。 IL2rgnull突变:Interleukin-2受体gamma链(IL-2Rγc,又称CD132)是具有重要免疫功能的细胞因子Il2、Il-4、Il-7、Il-9、Il-15和Il-21的共同受体亚基,该基因敲除后的小鼠机体免疫功能严重降低,通过多种受体阻断细胞因子信号传导,导致功能性NK细胞缺陷。 M-NSG严重免疫缺陷小鼠,缺失成熟T、B、NK细胞,可高效地植入人CD34+造血干细胞(HSC)、外周血单核细胞(PBMC)、病人来源异种移植物(PDX)或成体干细胞和组织,基本上可以植入人体免疫系统,是研究人体免疫功能,传染病,糖尿病,肿瘤学和干细胞生物学的重要免疫缺陷小鼠,是目前国际公认的免疫缺陷程度较高、较适合人源细胞或组织移植的工具小鼠。
应用领域:免疫及造血系统研究,肿瘤或细胞移植等。

验证数据

表型分析

M-NSG小鼠生长曲线

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图1. M-NSG小鼠生长曲线(n=600)


T、B、NK 细胞 FACS 检测

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图 2.M-NSG 小鼠脾脏(A)与外周血(B)中 T、B 和 NK 细胞缺失。取 BALB/c、M-NSG 小鼠的脾脏细胞与外周血,通过 FACS 对其中 T、B 和 NK 细胞的组成进行分析并进行统计对比


M、MΦ、DC 细胞 FACS 检测

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图 3.M-NSG 小鼠脾脏(A)与外周血(B)中 单核细胞、巨噬细胞和 DC 细胞比例。取 BALB/c、M-NSG 小鼠的脾脏细胞与外周血,通过 FACS 对其中单核细胞、巨噬细胞和 DC 细胞的组成进行分析并进行统计对比


血清抗体亚类检测

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图4. M-NSG小鼠血清抗体亚类检测(雄性,8周龄)。

各组织病理学检测


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图5. M-NSG 各组织病理学检测。A:除脾脏和胸腺外,其他组织未见明显异常,包括:脑、视网膜、脊髓、心脏、肝、肺、肾、小肠、大肠、胃、唾液腺、胰腺、卵巢、子宫、睾丸、附睾、骨骼肌、皮肤和棕色脂肪(雌性,6周龄);


M-NSG小鼠血常规检测

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M-NSG小鼠血生化检测

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CDX/PDX成瘤及药效验证

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图8. A549 肺肿瘤细胞(A)或 Raji 淋巴瘤细胞(B)在 M-NSG 小鼠上的成瘤验证。


基于 M-NSG 小鼠成功建立的 CDX 模型image.png


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图9.利用淋巴癌(Raji)CDX模型进行抗人CD47抗体药效验证实验。


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图10. 利用肺癌(A549)CDX模型进行CAR-T药效验证实验。

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图11. 移植CAR-T的M-NSG小鼠体内的GVHD研究。


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图12. 肝癌PDX在 M-NSG 小鼠上的成瘤验证。


人源免疫系统重建模型 

利用重度免疫缺陷M-NSG小鼠可以通过移植人源外周血细胞、造血干细胞等,实现在小鼠体内重塑人源免疫系统,为免疫学、肿瘤学及人类传染疾病等研究提供有力工具。


PBMC人源化小鼠

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Hu-PBMC模型,或者被称为Hu-PBL(perihperal blood lymphocyte, PBL)模型,是一种构建较为简单和经济的免疫系统人源化小鼠模型。Hu-PBMC模型的移植方式主要有腹腔注射与尾静脉注射,通常以4-6周龄的M-NSG小鼠作为移植受体,PBMC移植/接种量通常在5~10*10^6/小鼠。该模型常被用于研究人效应T细胞的活化以及评估免疫抑制药物。


Hu-PBMC模型的供体筛选


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图13.  M-NSG小鼠中进行Hu-PBMC重建的供体筛选。


image.png图14.流式分析Hu-PBMC模型外周血淋巴细胞亚群。将人PBMCs(5E6)静脉注射M-NSG小鼠(雌性,6-8周龄,n=4)。植入human PBMCs后取不同时间点的小鼠血液进行流式细胞分析。


image.png图15. 利用骨髓瘤(H929)Hu-PBMC模型进行体内药效研究。


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图16. 利用乳腺癌(MDA-MB-231)Hu-PBMC模型进行体内药效研究。


HSC人源化小鼠

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Hu-HSC模型,也叫hu-CD34+,或叫hu-SRC(scid-repopulatingcell),已经被广泛应用于研究人类造血发育、细胞介导的免疫反应以及HIV和EBV等病毒感染性疾病中。 其构建方式是将来自人脐带血、骨髓、G-CSF激活的外周血或胎肝的人CD34+ HSCs通过静脉内(i.v.)或股骨内(i.f.)注射到成年免疫缺陷小鼠M-NSG中,得到的小鼠可以产生多种造血干细胞。image.png


图17. M-NSG小鼠中进行Hu-HSC重建的供体筛选。

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图18. 流式分析Hu-HSC模型外周血淋巴细胞亚群。


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图19. 利用乳腺癌(MDA-MB-231)Hu-HSC模型进行体内药效研究。


发表文献 292篇

1. Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
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2. FOSL1 Orchestrates Epigenetic Reprogramming of Anaplastic Thyroid Cancer and Suppresses Natural Killer Cell-Mediated Antitumor Immunity
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8. Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors
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9. mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
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10. Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy
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14. Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy
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16. Silencing SFRP1 in bone mesenchymal stem cells alleviates pediatric B-ALL-driven bone loss by activating Wnt/β-catenin signaling
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17. Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC class I-deficient solid tumors
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18. Discovery of Oxime Ether Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer
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19. Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia
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22. ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications
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23. A novel human acute myeloid leukemia cell line SDEY-AML1 with KMT2A: MLLT3, IKZF1: EVX1 fusions exhibits high tumorigenicity in NSG mice
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30. Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
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31. USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination
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33. Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant Glioma
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34. Chemotherapy-Mediated Induction of PD-L1 via SEI1 Facilitates Myeloma Immune Evasion
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37. An Engineered Probiotic Consortium Based on Quorum-Sensing for Colorectal Cancer Immunotherapy
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38. SIRT5 inhibition impairs mitochondrial metabolism and enhances venetoclax-induced elimination of acute myeloid leukemia cells
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39. Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2
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41. 5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia
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43. BCL-2 mutant B7H6-CAR-T cells synergized with venetoclax for treating small cell lung cancer
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44. JMJD3 upregulates ALOX5 to drive malignancy and concomitant ferroptosis sensitivity in gastric cancer
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45. Low SVEP1 in intrahepatic cholangiocarcinoma mediates phenotype switching-driven metastasis by Jag2/Notch1/Hes5
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47. ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation
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51. Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model
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52. Retinoic acid enhances γδ T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion
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53. Histone acetylation activated-IGF2BP3 regulates cyclin D1 mRNA stability to drive cell cycle transition and tumor progression of hepatocellular carcinoma
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58. T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus
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71. COL4A2 drives ECM remodeling and stiffness increasing to promote breast cancer metastasis via YAP signaling pathway in dECM induced models
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72. Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways
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73. Chemical induction of ferroptosis through GPX4 inhibition: Rational Design of Triazole-Benzoxazine Hybrids for melanoma therapy
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74. Combination of anlotinib with immunotherapy enhanced both anti-angiogenesis and immune response in high-grade serous ovarian cancer
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75. High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer
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76. Scalable Matrigel-Free Suspension Culture for Generating High-Quality Human Liver Ductal Organoids
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77. Preclinical Development and a Case Report of a Nanobody-Based CLDN18.2 CAR-T IMC002 with Reduced On-Target Off-Tumor Toxicity
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83. Cbl-b inhibition improves manufacturing efficiency and antitumoral efficacy of anti-CD19 CAR-T cells
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85. NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia
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发表年份:2024 来源杂志:NATURE BIOTECHNOLOGY

100. The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma
发表年份:2024 来源杂志:Cancer Discovery

101. Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
发表年份:2024 来源杂志:Cell Metabolism

102. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
发表年份:2024 来源杂志:Cell Metabolism

103. A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway
发表年份:2024 来源杂志:Molecular Cancer

104. Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors
发表年份:2024 来源杂志:ADVANCED MATERIALS

105. An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity
发表年份:2024 来源杂志:ADVANCED MATERIALS

106. Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone
发表年份:2024 来源杂志:Nature Biomedical Engineering

107. Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
发表年份:2024 来源杂志:Cell Stem Cell

108. FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
发表年份:2024 来源杂志:Nature Communications

109. Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
发表年份:2024 来源杂志:Nature Communications

110. PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
发表年份:2024 来源杂志:Nature Communications

111. Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy
发表年份:2024 来源杂志:Nature Communications

112. Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice
发表年份:2024 来源杂志:Nature Communications

113. Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity
发表年份:2024 来源杂志:Nature Communications

114. Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
发表年份:2024 来源杂志:Nature Communications

115. Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies
发表年份:2024 来源杂志:Nature Communications

116. ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms
发表年份:2024 来源杂志:Autophagy

117. Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis
发表年份:2024 来源杂志:Advanced Science

118. Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development
发表年份:2024 来源杂志:Advanced Science

119. SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer
发表年份:2024 来源杂志:Advanced Science

120. SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis
发表年份:2024 来源杂志:Advanced Science

121. A pan-KRAS degrader for the treatment of KRAS-mutant cancers
发表年份:2024 来源杂志:Cell Discovery

122. ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
发表年份:2024 来源杂志:LEUKEMIA

123. Anagrelide and idarubicin combination induces GSDME-mediated pyroptosis as a potential therapy for high-PDE3A acute myeloid leukemia
发表年份:2024 来源杂志:LEUKEMIA

124. Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
发表年份:2024 来源杂志:CANCER RESEARCH

125. Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma
发表年份:2024 来源杂志:CANCER RESEARCH

126. Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia
发表年份:2024 来源杂志:CANCER RESEARCH

127. PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression
发表年份:2024 来源杂志:CANCER RESEARCH

128. HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
发表年份:2024 来源杂志:Theranostics

129. Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease
发表年份:2024 来源杂志:Gut Microbes

130. Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia
发表年份:2024 来源杂志:Cell Reports Medicine

131. Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors
发表年份:2024 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

132. Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia
发表年份:2024 来源杂志:Journal of Advanced Research

133. Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies
发表年份:2024 来源杂志:Journal of Advanced Research

134. Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia
发表年份:2024 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

135. LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
发表年份:2024 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

136. USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERα
发表年份:2024 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

137. iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation
发表年份:2024 来源杂志:MedComm

138. Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy
发表年份:2024 来源杂志:JOURNAL OF NANOBIOTECHNOLOGY

139. RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment
发表年份:2024 来源杂志:Journal for ImmunoTherapy of Cancer

140. ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
发表年份:2024 来源杂志:Journal for ImmunoTherapy of Cancer

141. ImmunoPET imaging of LAG-3 expression in tumor microenvironment with 68Ga-labelled cyclic peptides tracers: from bench to bedside
发表年份:2024 来源杂志:Journal for ImmunoTherapy of Cancer

142. Engineered oncolytic virus expressing B7H3-targeting BiTE enhances antitumor T-cell immune response
发表年份:2024 来源杂志:Journal for ImmunoTherapy of Cancer

143. Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
发表年份:2024 来源杂志:EMBO JOURNAL

144. Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
发表年份:2024 来源杂志:Cell Communication and Signaling

145. KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis
发表年份:2024 来源杂志:International Journal of Biological Sciences

146. The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment
发表年份:2024 来源杂志:Cell Death & Disease

147. A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
发表年份:2024 来源杂志:Cell Death & Disease

148. EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification
发表年份:2024 来源杂志:JOURNAL OF AUTOIMMUNITY

149. Connexin 25 maintains self-renewal and functions of airway basal cells for airway regeneration
发表年份:2024 来源杂志:Stem Cell Research & Therapy

150. Human umbilical cord mesenchymal stem cell-based gene therapy for hemophilia B using scAAV-DJ/8-LP1-hFIXco transduction
发表年份:2024 来源杂志:Stem Cell Research & Therapy

151. Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer
发表年份:2024 来源杂志:BIOMEDICINE & PHARMACOTHERAPY

152. IGSF9 promotes tumor invasion and metastasis through GSK-3β/β-catenin mediated EMT in lung cancer
发表年份:2024 来源杂志:NEOPLASIA

153. TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway
发表年份:2024 来源杂志:Journal of Translational Medicine

154. IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer
发表年份:2024 来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY

155. Oncolytic virus encoding 4-1BBL and IL15 enhances the efficacy of tumor-infiltrating lymphocyte adoptive therapy in HCC
发表年份:2024 来源杂志:CANCER GENE THERAPY

156. ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer
发表年份:2024 来源杂志:Translational Oncology

157. Effective in vivo reactivation of HIV-1 latency reservoir via oral administration of EK-16A-SNEDDS
发表年份:2024 来源杂志:EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

158. Single-cell RNA-sequencing reveals a profound immune cell response in human cytomegalovirus-infected humanized mice
发表年份:2024 来源杂志:VIROLOGICA SINICA

159. Generation of self-renewing neuromesodermal progenitors with neuronal and skeletal muscle bipotential from human embryonic stem cells
发表年份:2024 来源杂志:Cell Reports Methods

160. PLA2G2D promotes immune escape in non-small cell lung cancer by regulating T cell immune function through PD-L1-expressing extracellular vesicles
发表年份:2024 来源杂志:SCANDINAVIAN JOURNAL OF IMMUNOLOGY

161. Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer
发表年份:2024 来源杂志:Biomedicines

162. Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity
发表年份:2024 来源杂志:ACS Omega

163. FYB1-targeted modulation of CAPG promotes AML progression
发表年份:2024 来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY

164. The DHODH inhibitor teriflunomide impedes cell proliferation and enhances chemosensitivity to daunorubicin (DNR) in T-cell acute lymphoblastic leukemia
发表年份:2024 来源杂志:ANNALS OF HEMATOLOGY

165. PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome
发表年份:2024 来源杂志:DNA AND CELL BIOLOGY

166. Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice
发表年份:2024 来源杂志:Journal of Gastrointestinal Oncology

167. Restoring T and B cell generation in X-linked severe combined immunodeficiency mice through hematopoietic stem cells adenine base editing
发表年份:2024 来源杂志:MOLECULAR THERAPY

168. Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification
发表年份:2024 来源杂志:PHARMACOLOGICAL RESEARCH

169. miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair
发表年份:2024 来源杂志:JACC-Basic to Translational Science

170. Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis
发表年份:2024 来源杂志:International Journal of Biological Sciences

171. LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma
发表年份:2024 来源杂志:Cell Death & Disease

172. Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation
发表年份:2024 来源杂志:Cell Death & Disease

173. Small extracellular vesicle piR-hsa-30937 derived from pancreatic neuroendocrine neoplasms upregulates CD276 in macrophages to promote immune evasion
发表年份:2024 来源杂志:Cancer Immunology Research

174. Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
发表年份:2024 来源杂志:Cell Reports

175. Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation
发表年份:2024 来源杂志:Stem Cell Research & Therapy

176. Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation
发表年份:2024 来源杂志:PHYTOMEDICINE

177. Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
发表年份:2024 来源杂志:OncoImmunology

178. PHE1-based IgG-like antibody platform provides a novel strategy for enhanced T-cell immunotherapy
发表年份:2024 来源杂志:Frontiers in Immunology

179. INPP4B suppresses HER2-induced mesenchymal transition in HER2+ breast cancer and enhances sensitivity to Lapatinib
发表年份:2024 来源杂志:BIOCHEMICAL PHARMACOLOGY

180. The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
发表年份:2024 来源杂志:MOLECULAR CANCER THERAPEUTICS

181. TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B-cell lymphomas
发表年份:2024 来源杂志:LIFE SCIENCES

182. FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis
发表年份:2024 来源杂志:Communications Biology

183. HDAC inhibitors target IRS4 to enhance anti‑AR therapy in AR‑positive triple‑negative breast cancer
发表年份:2024 来源杂志:INTERNATIONAL JOURNAL OF ONCOLOGY

184. Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model
发表年份:2024 来源杂志:EJNMMI Radiopharmacy and Chemistry

185. PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome
发表年份:2024 来源杂志:DNA AND CELL BIOLOGY

186. Exosome-derived circCCAR1 promotes CD8+T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023-03-18 来源杂志:Molecular Cancer

187. A novel antidiuretic hormone governs tumour-induced renal dysfunction
发表年份:2023 来源杂志:NATURE

188. Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals
发表年份:2023 来源杂志:CELL

189. Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
发表年份:2023 来源杂志:Signal Transduction and Targeted Therapy

190. Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023 来源杂志:Molecular Cancer

191. Tumors evade immune cytotoxicity by altering the surface topology of NK cells
发表年份:2023 来源杂志:NATURE IMMUNOLOGY

192. Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress
发表年份:2023 来源杂志:GASTROENTEROLOGY

193. Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain
发表年份:2023 来源杂志:Cell Metabolism

194. The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
发表年份:2023 来源杂志:Cellular & Molecular Immunology

195. STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
发表年份:2023 来源杂志:NATURE CELL BIOLOGY

196. Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells
发表年份:2023 来源杂志:Nature Communications

197. SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
发表年份:2023 来源杂志:Nature Communications

198. Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
发表年份:2023 来源杂志:Nature Communications

199. Sequence-based drug design as a concept in computational drug design
发表年份:2023 来源杂志:Nature Communications

200. TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
发表年份:2023 来源杂志:Nature Communications

201. Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors
发表年份:2023 来源杂志:Cancer Communications

202. Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins
发表年份:2023 来源杂志:Cancer Communications

203. Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling
发表年份:2023 来源杂志:JOURNAL OF CLINICAL INVESTIGATION

204. Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s
发表年份:2023 来源杂志:JOURNAL OF EXPERIMENTAL MEDICINE

205. CAR-Aptamers Enable Traceless Enrichment and Monitoring of CAR-Positive Cells and Overcome Tumor Immune Escape
发表年份:2023 来源杂志:Advanced Science

206. NIRF/PET imaging of γδ T cells via metabolic glycoengineering and bioorthogonal labeling
发表年份:2023 来源杂志:CHEMICAL ENGINEERING JOURNAL

207. Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA-Seq
发表年份:2023 来源杂志:Advanced Science

208. Targeted therapy of central nervous system acute lymphoblastic leukemia with an integrin α6-targeted self-assembling proapoptotic nanopeptide
发表年份:2023 来源杂志:Engineering

209. Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis
发表年份:2023 来源杂志:Gut Microbes

210. Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
发表年份:2023 来源杂志:LEUKEMIA

211. TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
发表年份:2023 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

212. Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
发表年份:2023 来源杂志:CANCER RESEARCH

213. PICH activates Cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer.
发表年份:2023 来源杂志:CANCER RESEARCH

214. Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA-4 and PD-1 checkpoint blockade
发表年份:2023 来源杂志:CANCER RESEARCH

215. Targeted glycan degradation potentiates cellular immunotherapy for solid tumors
发表年份:2023 来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

216. Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia
发表年份:2023 来源杂志:Biomarker Research

217. TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
发表年份:2023 来源杂志:JOURNAL OF NANOBIOTECHNOLOGY

218. DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response
发表年份:2023 来源杂志:HAEMATOLOGICA

219. Tissue factor overexpression in triple-negative breast cancer promotes immune evasion by impeding T-cell infiltration and effector function
发表年份:2023 来源杂志:CANCER LETTERS

220. Covalent targeting the LAS1-NOL9 axis for selective treatment in NPM1 mutant acute myeloid leukemia
发表年份:2023 来源杂志:PHARMACOLOGICAL RESEARCH

221. PARP inhibitor exerts an anti-tumor effect via LMO2 and synergizes with cisplatin in natural killer/T cell lymphoma
发表年份:2023 来源杂志:BMC Medicine

222. Alternative splicing of HOXB-AS3 underlie the promoting effect of nuclear m6A reader YTHDC1 on the self-renewal of leukemic stem cells in acute myeloid leukemia
发表年份:2023 来源杂志:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

223. TGF-β blocking combined with photothermal therapy promote tumor targeted migration and long-term antitumor activity of CAR-T cells
发表年份:2023 来源杂志:Materials Today Bio

224. Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities
发表年份:2023 来源杂志:ACTA PHARMACOLOGICA SINICA

225. Hypoimmunogenic human pluripotent stem cells are valid cell sources for cell therapeutics with normal self-renewal and multilineage differentiation capacity
发表年份:2023 来源杂志:Stem Cell Research & Therapy

226. Bispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager
发表年份:2023 来源杂志:Frontiers in Immunology

227. SIGLEC10+ macrophages drive gastric cancer progression by suppressing CD8+ T cell function
发表年份:2023 来源杂志:CANCER IMMUNOLOGY IMMUNOTHERAPY

228. Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma
发表年份:2023 来源杂志:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

229. CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing
发表年份:2023 来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY

230. Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo
发表年份:2023 来源杂志:VIROLOGICA SINICA

231. Bruton tyrosine kinase inhibitors preserve anti-CD19 chimeric antigen receptor T-cell functionality and reprogram tumor micro-environment in B-cell lymphoma
发表年份:2023 来源杂志:CYTOTHERAPY

232. A second-generation CD38-CAR-T cell for the treatment of multiple myeloma
发表年份:2023 来源杂志:Cancer Medicine

233. Oxymatrine boosts hematopoietic regeneration by modulating MAPK/ERK phosphorylation after irradiation-induced hematopoietic injury
发表年份:2023 来源杂志:EXPERIMENTAL CELL RESEARCH

234. PD-L1 ImmunoPET on the basis of Avidin/Biotin pre-targeted cancer imaging
发表年份:2023 来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

235. T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022-07-26 来源杂志:nature communications

236. A Chimeric Conjugate of Antibody and Programmable DNA Nanoassembly Smartly Activates T cell for Precise Cancer Cell Targeting
发表年份:2022-06-24 来源杂志:A Journal of the Gesellschaft Deutscher Chemiker

237. BSA-AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma
发表年份:2022 来源杂志:ADVANCED MATERIALS

238. Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy
发表年份:2022 来源杂志:Nature Biomedical Engineering

239. T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022 来源杂志:Nature Communications

240. Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica
发表年份:2022 来源杂志:Nature Communications

241. Modeling Human Thyroid Development by Fetal Tissue-Derived Organoid Culture
发表年份:2022 来源杂志:Advanced Science

242. Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti-Leukemia Efficacy of CAR-T Cells via SOCE-Calcineurin-NFAT and Glycolysis Pathways
发表年份:2022 来源杂志:Advanced Science

243. Nano-Biohybrid DNA Engager That Reprograms the T-Cell Receptor
发表年份:2022 来源杂志:Journal of the American Chemical Society

244. Therapeutic strategies targeting uPAR potentiate anti–PD-1 efficacy in diffuse-type gastric cancer
发表年份:2022 来源杂志:Science Advances

245. Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia
发表年份:2022 来源杂志:Acta Pharmaceutica Sinica B

246. An armed oncolytic virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen-presenting cells in situ
发表年份:2022 来源杂志:MOLECULAR THERAPY

247. Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction
发表年份:2022 来源杂志:LEUKEMIA

248. FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
发表年份:2022 来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

249. Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL
发表年份:2022 来源杂志:CELL DEATH AND DIFFERENTIATION

250. Visualizing γδ T cells by very late antigen-4-targeted positron emission tomography
发表年份:2022 来源杂志:EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

251. Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2
发表年份:2022 来源杂志:Cell Reports

252. Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations
发表年份:2022 来源杂志:Cell Reports

253. Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma
发表年份:2022 来源杂志:Cell Death & Disease

254. Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma
发表年份:2022 来源杂志:Cell Death & Disease

255. LncSIK1 enhanced the sensitivity of AML cells to retinoic acid by the E2F1/autophagy pathway
发表年份:2022 来源杂志:CELL PROLIFERATION

256. Gene therapy with B-cell maturation antigen/CD3 bispecific antibody encoding plasmid DNA for treating multiple myeloma
发表年份:2022 来源杂志:BRITISH JOURNAL OF HAEMATOLOGY

257. Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells
发表年份:2022 来源杂志:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

258. SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
发表年份:2022 来源杂志:Frontiers in Pharmacology

259. Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin
发表年份:2022 来源杂志:Frontiers in Pharmacology

260. Large-cohort humanized NPI mice reconstituted with CD34+ hematopoietic stem cells are feasible for evaluating preclinical cancer immunotherapy
发表年份:2022 来源杂志:FASEB JOURNAL

261. Preclinical Assessment of MEK Inhibitors for Malignant Peripheral Nerve Sheath Tumors Reveals Differences in Efficacy and Adaptive Response
发表年份:2022 来源杂志:Frontiers in Oncology

262. ABCC6 Knockdown Fuels Cell Proliferation by Regulating PPARα in Hepatocellular Carcinoma
发表年份:2022 来源杂志:Frontiers in Oncology

263. LncRNA SNHG3 enhances BMI1 mRNA stability by binding and regulating c-MYC: Implications for the carcinogenic role of SNHG3 in bladder cancer
发表年份:2022 来源杂志:Cancer Medicine

264. Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
发表年份:2021 来源杂志:SCIENCE

265. A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity
发表年份:2021 来源杂志:Science Translational Medicine

266. The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
发表年份:2021 来源杂志:MOLECULAR CELL

267. CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase
发表年份:2021 来源杂志:HEPATOLOGY

268. DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression
发表年份:2021 来源杂志:CANCER RESEARCH

269. Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma
发表年份:2021 来源杂志:CLINICAL CANCER RESEARCH

270. WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
发表年份:2021 来源杂志:Acta Pharmaceutica Sinica B

271. TIGIT-Fc Promotes Antitumor Immunity
发表年份:2021 来源杂志:Cancer Immunology Research

272. FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53
发表年份:2021 来源杂志:ONCOGENE

273. Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model
发表年份:2021 来源杂志:Frontiers in Immunology

274. Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells
发表年份:2021 来源杂志:Stem Cell Research & Therapy

275. Engineering mesenchymal stromal cells with neutralizing and anti-inflammatory capability against SARS-CoV-2 infection
发表年份:2021 来源杂志:Molecular Therapy-Methods & Clinical Development

276. Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis
发表年份:2021 来源杂志:Cancers

277. A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms
发表年份:2021 来源杂志:ACTA PHARMACOLOGICA SINICA

278. Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy
发表年份:2021 来源杂志:Frontiers in Bioengineering and Biotechnology

279. Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy
发表年份:2021 来源杂志:Frontiers in Pharmacology

280. RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells
发表年份:2021 来源杂志:Stem Cell Reviews and Reports

281. Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway
发表年份:2021 来源杂志:PHYTOMEDICINE

282. CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway
发表年份:2021 来源杂志:Nanoscale Research Letters

283. NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair
发表年份:2021 来源杂志:AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

284. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China
发表年份:2021 来源杂志:Annals of Translational Medicine

285. Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
发表年份:2020 来源杂志:CELL

286. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
发表年份:2020 来源杂志:Nature Communications

287. Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane-bound and secreted β2m-HLA-G fusion proteins
发表年份:2020 来源杂志:STEM CELLS

288. 4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
发表年份:2020 来源杂志:Frontiers in Immunology

289. Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models
发表年份:2020 来源杂志:Frontiers in Oncology

290. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation
发表年份:2020 来源杂志:Aging-US

291. Lgr5 maintains stemness and regulates cell property in nasopharyngeal carcinoma through Wnt/β-catenin signaling pathway
发表年份:2020 来源杂志:Stem Cell Research

292. Peptide Self-Assembly Nanoparticles Loaded with Panobinostat to Activate Latent Human Immunodeficiency Virus
发表年份:2019-05-01 来源杂志:J Biomed Nanotechnol

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