Alb-CreERT2

品系全名

B6.129S-Albtm1.1(CreERT2)Smoc

目录号

NM-KI-00002

品系状态

活体

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基因信息

基因名
ALB

品系描述

将CreERT2表达框定点敲入小鼠内源Alb基因ATG位置,建立Tamoxifen诱导的Alb-Cre工具鼠。该品系已去除Neo筛选基因。该小鼠是研究肝脏基因功能与疾病的重要小鼠品系。
应用领域:肝脏特异

验证数据

alb-creERT2-1.png

Fig1 Alb-CreERT2; Rosa26-LacZ小鼠肝组织X-gal染色。未使用他莫昔芬诱导的小鼠,肝细胞未被染色;使用他莫昔芬诱导的小鼠,肝细胞成功着色,证明Alb-CreERT2小鼠可以成为实现肝脏时间特异性敲除或表达的工具鼠。

alb-creERT2-2.png

Fig2 Alb-CreERT2; Rosa26-LacZ小鼠肝组织免疫荧光检测。Alb-CreERT2; Rosa26-LacZ小鼠被他莫昔芬诱导后,LacZ(红色)表达,证明Alb-CreERT2小鼠可以成为实现肝脏时间特异性敲除或表达的工具鼠。


alb-creERT2-3.png


Fig3  Alb-CreERT2小鼠血生化检测。结果显示Alb-CreERT2小鼠与野生型小鼠相比肝功能正常。



发表文献 26篇

1. Loss of hepatic ME1 ameliorates MASLD by Suppressing peroxisomal β-Oxidation and Activating Lipophagy/Lipolysis
发表年份:2025 来源杂志:Journal of Advanced Research

2. Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology
发表年份:2025 来源杂志:npj Parkinsons Disease

3. LGR4 is a key regulator of hepatic gluconeogenesis
发表年份:2025 来源杂志:FREE RADICAL BIOLOGY AND MEDICINE

4. Zinc finger BED-type containing 3 promotes hepatic steatosis by interacting with polypyrimidine tract-binding protein 1
发表年份:2024 来源杂志:DIABETOLOGIA

5. Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
发表年份:2024 来源杂志:INFLAMMATION RESEARCH

6. AHR regulates liver enlargement and regeneration through the YAP signaling pathway
发表年份:2024 来源杂志:Heliyon

7. Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
发表年份:2023 来源杂志:NEURON

8. Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury
发表年份:2023 来源杂志:Autophagy

9. Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice
发表年份:2023 来源杂志:Cell Death & Disease

10. PPM1H is down-regulated by ATF6 and dephosphorylates p-RPS6KB1 to inhibit progression of hepatocellular carcinoma
发表年份:2023 来源杂志:Molecular Therapy-Nucleic Acids

11. Hepatocyte CD36 protects mice from NASH diet-induced liver injury and fibrosis via blocking N1ICD production
发表年份:2023 来源杂志:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

12. Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
发表年份:2023 来源杂志:Cells

13. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway
发表年份:2023 来源杂志:Nutrients

14. CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
发表年份:2023 来源杂志:iScience

15. Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors
发表年份:2022 来源杂志:MOLECULAR THERAPY

16. Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine–Induced Acute Liver Failure Through Inhibiting GSK3β–Nrf2–Mediated Hepatocyte Apoptosis and Ferroptosis
发表年份:2022 来源杂志:Cellular and Molecular Gastroenterology and Hepatology

17. Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response
发表年份:2021 来源杂志:Aging-US

18. Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy
发表年份:2021 来源杂志:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

19. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride
发表年份:2020 来源杂志:ACTA PHARMACOLOGICA SINICA

20. STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma
发表年份:2020 来源杂志:ACTA BIOCHIMICA ET BIOPHYSICA SINICA

21. HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition
发表年份:2019 来源杂志:CANCER RESEARCH

22. Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
发表年份:2019 来源杂志:Cell Reports

23. Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway
发表年份:2018 来源杂志:Cell Death & Disease

24. Enhancing the precision of genetic lineage tracing using dual recombinases
发表年份:2017 来源杂志:NATURE MEDICINE

25. Fate tracing of hepatocytes in mouse liver
发表年份:2017 来源杂志:Scientific Reports

26. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
发表年份:2016 来源杂志:Oncotarget

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