Foxp3-IRES-DTRGFP

品系全名

C57BL/6JSmo-Foxp3em3(IRES-DTREGFP)Smoc

目录号

NM-KI-190046

品系状态

活体

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基因信息

基因名
Foxp3

基因曾用名

sf; JM2; scurfin

NCBI ID

20371

MGI ID

1891436

Ensembl ID

ENSMUSG00000039521

Pubmed

Foxp3

人类同源基因

FOXP3

品系描述

将IRES-DTREGFP共表达结构插入到小鼠Foxp3基因终止密码子处。
应用领域：DTR工具鼠

验证数据

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Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. 

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Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT).

foxp3-DTR-2.png

Fig3. The percent of  Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

foxp3-DTR-3.png

Fig4. The percent of  Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

foxp3-DTR-4.png

Fig5.  The growth of MC38 tumors in Foxp3-IRES-DTRGFP mice and C57BL/6 mice. (In collaboration with CrownBio) 

发表文献 10篇

1. DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice
发表年份：2026 来源杂志：Nature Communications

2. Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages
发表年份：2025 来源杂志：Nature Microbiology

3. Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates
发表年份：2025 来源杂志：Advanced Science

4. Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5
发表年份：2025 来源杂志：Gut Microbes

5. Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury
发表年份：2025 来源杂志：Neurotherapeutics

6. Immuno-protective vesicle-crosslinked hydrogel for allogenic transplantation
发表年份：2024 来源杂志：Nature Communications

7. Treg cells-derived exosomes promote blood-spinal cord barrier repair and motor function recovery after spinal cord injury by delivering miR-2861
发表年份：2023 来源杂志：JOURNAL OF NANOBIOTECHNOLOGY

8. Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition
发表年份：2023 来源杂志：CNS Neuroscience & Therapeutics

9. Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment
发表年份：2022 来源杂志：Scientific reports

10. Lenvatinib Targets FGF Receptor 4 to Enhance Antitumor Immune Response of Anti–Programmed Cell Death-1 in HCC
发表年份：2021 来源杂志：HEPATOLOGY

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