Cd8a-IRES-Luc-2A-EGFP

品系全名

C57BL/6JSmo-Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc

目录号

NM-KI-18030

品系状态

胚胎冻存

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基因信息

基因名
Cd8a

品系描述

在Cd8a基因终止密码子TAA之前定点敲入V5-IRES-luci-2A-EGFP表达框,建立带有V5、luci荧光素酶以及EGFP荧光蛋白多重标记的Cd8a基因敲入小鼠模型。
应用领域:示踪

验证数据

Cd8a-V5-IRES-Akaluc-2A-EGFP mouse model_05.png

Fig. 1  在没有任何刺激的状态下,活体成像系统检测出Cd8aV5-IRES-luci-2A-EGFP/+小鼠相比野生型小鼠,会呈现明显荧光


Cd8a-V5-IRES-Akaluc-2A-EGFP mouse model_06.png

Fig. 2  Cd8aV5-IRES-luci-2A-EGFP/+小鼠MC38荷瘤模型活体成像验证。PD1抗体药物刺激1天后,荧光明显增强

Cd8aV5-IRES-luci-2A-EGFP-3.png

Fig. 3  Cd8aV5-IRES-luci-2A-EGFP/+小鼠外周血中EGFP的表达


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