C57BL/6

品系全名

C57BL/6Smoc

目录号

SM-001

品系状态

活体

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品系描述

是第一个完成基因组测序的小鼠品系，毛色为黑色，被认作"标准"的近交系，为许多突变基因提供遗传背景。具有品系稳定、易于繁殖，应激反应均一，试验结果精度高等特点。

验证数据

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图1.C57BL/6小鼠生长曲线（n=840）。

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图2.C57BL/6小鼠血常规检测。


发表文献 26篇

1. Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome
发表年份：2025 来源杂志：Signal Transduction and Targeted Therapy

2. Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis
发表年份：2025 来源杂志：Advanced Science

3. High-Resolution Multiplexed Sequencing of Single-Cell Full-length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion
发表年份：2025 来源杂志：Advanced Science

4. Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
发表年份：2025 来源杂志：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

5. Targeting the ac4C ‘Writer’ NAT10 enhances pancreatic cancer immunotherapy via dual modulation of CD8+ T cells and tumor cells
发表年份：2025 来源杂志：Cell Death & Disease

6. Extracellular vesicles for delivery of functional telomerase
发表年份：2025 来源杂志：Cell Communication and Signaling

7. An injectable cisplatin hydrogel effectively suppresses tumors while preserving anti-infective immunity
发表年份：2025 来源杂志：MATERIALS & DESIGN

8. The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue
发表年份：2025 来源杂志：npj Science of Food

9. Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
发表年份：2025 来源杂志：Cell Reports

10. Activated T cells degrade extracellular proteins to enhance effector functions
发表年份：2025 来源杂志：Cell Reports

11. Therapeutic efficacy of Sanhuang Xiexin decoction on atopic dermatitis via suppressing STAT3 signaling
发表年份：2025 来源杂志：JOURNAL OF ETHNOPHARMACOLOGY

12. Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess
发表年份：2025 来源杂志：Biology of Sex Differences

13. α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice
发表年份：2025 来源杂志：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

14. Therapeutic Efficacy and Mechanistic Insights of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Chemotherapy-Induced Oral Mucositis
发表年份：2025 来源杂志：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

15. Integrating global burden of disease analysis and single-cell omics identifies ANTXR2 as a potential diagnostic biomarker for AML in China
发表年份：2025 来源杂志：INTERNATIONAL IMMUNOPHARMACOLOGY

16. Andrographolide inhibits the upregulation of SLC19A3 to block the adipogenic differentiation of adipose-derived stem cells
发表年份：2025 来源杂志：iScience

17. Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life
发表年份：2025 来源杂志：Scientific Reports

18. Blockade of CD47 signaling improves ferroptosis of lung cancer cells via activating Nrf2/FPN signaling
发表年份：2025 来源杂志：CELLULAR SIGNALLING

19. Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma
发表年份：2025 来源杂志：CELLULAR SIGNALLING

20. Optical characterization of ocular collagen microstructure and anisotropy in animal and human eyes
发表年份：2025 来源杂志：Biomedical Optics Express

21. Asiaticoside protects against PDF-induced peritoneal fibrosis via suppression of AhR/Nrf2-mediated MMT and oxidative stress
发表年份：2025 来源杂志：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

22. A multi-omics landscape of programmed cell death in acetaminophen-induced acute kidney injury
发表年份：2025 来源杂志：RENAL FAILURE

23. USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
发表年份：2025 来源杂志：American Journal of Cancer Research

24. Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression
发表年份：2025 来源杂志：DIGESTIVE DISEASES AND SCIENCES

25. Protocol for co-culture of primary neurons and organotypic hippocampal brain slices from mice
发表年份：2025 来源杂志：STAR Protocols

26. Extending dual-targeting upper-limit in liposomal delivery of lithospermic acid B for Alzheimer's mitochondrial revitalization
发表年份：2024 来源杂志：JOURNAL OF CONTROLLED RELEASE

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