hLTBR

品系全名

C57BL/6Smoc-Ltbrem1(hLTBR)Smoc

目录号

NM-HU-241682

品系状态

活体

导出PDF

基因信息

基因名
Ltbr

品系描述

利用同源重组,将小鼠Ltbr基因进行人源化修饰。

验证数据

image.png

Fig.1 Expression analysis of hLTBR and mLTBR on macrophages and DCs in spleen of hLTBR humanized mice. 

Leukocytes were collected from wild-type C57BL/6 mice (female, 8 weeks) and homozygous hLTBR mice (female, 8 weeks), and analyzed by flow cytometry with anti-mouse LTBR and anti-human LTBR. hLTBR were exclusively detectable in LTBR humanized mice but not in wild-type mice.

image.png

Fig.2 Expression analysis of hLTBR and mLTBR on macrophages and DCs in blood of hLTBR humanized mice. 

Leukocytes were collected from wild-type C57BL/6 mice (female, 8 weeks) and homozygous hLTBR mice (female, 8 weeks), and analyzed by flow cytometry with anti-mouse LTBR and anti-human LTBR. hLTBR were exclusively detectable in LTBR humanized mice but not in wild-type mice.

image.png

Fig.3 Expression analysis of hLTBR and mLTBR on macrophages and DCs in bone marrow (BM) of hLTBR humanized mice. 

Leukocytes were collected from wild-type C57BL/6 mice (female, 8 weeks) and homozygous hLTBR mice (female, 8 weeks), and analyzed by flow cytometry with anti-mouse LTBR and anti-human LTBR. hLTBR were exclusively detectable in LTBR humanized mice but not in wild-type mice.


你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式,包括基因定点修饰的小鼠命名,比如:敲除、敲入、点突变等等,和随机转基因的小鼠命名。

查看