hPCSK9(2)
品系全名
C57BL/6Smoc-Pcsk9tm2(hPCSK9)Smoc
目录号
NM-HU-230151
品系状态
活体
基因信息
基因名
Pcsk9
品系描述
利用同源重组，将小鼠Pcsk9 基因进行人源化修饰。
*使用本品系发表的文献需注明: hPCSK9(2) mice (Cat. NO. NM-HU-230151) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 Detection of PCSK9 expression in liver by RT-PCR.
Wild type: only one band at 177 bp with primers F1/R1(mPcsk9);
Homozygous: only one band at 188 bp with primers F2/R2(hPCSK9).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of human PCSK9 expression in serum by ELISA (n=6).
Abb. hPCSK9: NM-HU-00075
Fig.3 Blood biochemical testing of lipid profiles in hPCSK9(2) mice.
The results revealed that hPCSK9(2) mice exhibited significantly reduced LDL-cholesterol levels compared to the wild-type mice. (n=5 or 6 /group).
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