hIL3-hCSF2-Tg(M-NSG)

品系全名

NOD.Cg-PrkdcscidIl2rgem1Tg(hIL3-hCSF2)Smoc

目录号

NM-KI-215006

品系状态

活体

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基因信息

基因名
IL3

基因名
CSF2

品系描述

利用转基因技术将人源IL3和人源CSF2基因表达框整合到小鼠基因组中,从而表达人源IL3和人源CSF2。

验证数据

image.png

Fig.1 Detection of hCSF2(A) and hIL3(B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; N.D. not detected.

image.png

Fig. 2 Human immune cell phenotyping in hIL3-hCSF2-transgenic (M-NSG) engrafted with human HSCs. Human CD34+ cells (1.0×10^5) were intravenously injected into homozygous hIL3-hCSF2-transgenic (M-NSG) pretreated with 1.0 Gy irradiation. These results demonstrate successful engraftment and propagation of human T, B, Myeloid and Momocytescells in the hIL3-hCSF2-transgenic (M-NSG) model.


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