hIL4-Tg(M-NSG)
品系全名
NOD.Cg-PrkdcscidIl2rgem1Tg(hIL4)Smoc
目录号
NM-KI-215004
品系状态
胚胎冻存
基因信息
基因名
Il4
品系描述
验证数据
Fig 1. Detection of IL4 expression in adrenal, intestine and lung of 8-week-old male mice by RT-PCR.
Wild type: Only one band at 123 bp with primers F/R(mGapdh).
Homozygous: One band at 223 bp with primers F1/R1(hIL4) and one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig 2. Detection of IL4 expression in adrenal, intestine and lung of 8-week-old male mice by qPCR (n=2).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig 3. Detection of human IL4 expression in serum of 8-week-old male mice by ELISA (n=2).
Abbr. HO, homozygous; WT, wild type; N.D. not detected.
Fig 4. Body weight growth curve of huPBMC-M-NSG-hIL4 mice.
Fig 4. Survival rate of huPBMC-M-NSG-hIL4 mice.
Fig 5. GvHD scores of huPBMC-M-NSG-hIL4 mice.
Fig 6. Percentage of hCD45-positive cells in peripheral blood of huPBMC-M-NSG-hIL4 mice.
Fig 7. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-M-NSG-hIL4 model. Human PBMCs (1E7) were injected intravenously into hIL4-Tg(M-NSG) mice (female, 6-8 weeks old, n=10). Blood from mice at different time points after implantation of human PBMCs was taken for flow cytometric analysis.
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