Fcgr2b-2A-CreERT2
品系全名
C57BL/6Smoc-Fcgr2bem1(2A-CreERT2)Smoc
目录号
NM-KI-241661
品系状态
精子冻存
基因信息
基因名
Fcgr2b
品系描述
将2A-CreERT2插入到小鼠Fcgr2b基因终止密码子处。
*使用本品系发表的文献需注明: Fcgr2b-2A-CreERT2 mice (Cat. NO. NM-KI-241661) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. CreERT2 mediated recombination in lung of Fcgr2bCreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Fcgr2bCreERT2/+; Rosa26tdTomato/+ mouse. Tissues expressing tdTomato following tamoxifen induction: Spleen, liver, lung, kidney, small intestine, colon, vagina and mesenteric lymph nodes. No significant fluorescence expression was observed in the brain, spinal cord, eye and reproductive system following tamoxifen induction. (38-days old, female) (For more detailed information please contact our technical advisor.)
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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