Cd4-CreERT2
品系全名
C57BL/6Smoc-Cd4em1(CreERT2-pA)Smoc
目录号
NM-KI-234689
品系状态
活体
基因信息
基因名
Cd4
品系描述
鉴定报告
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Fig.1 Detection of tdTomato expression in CD4+ T in spleen, blood and thymus of HE 26-CAG-LSL-tdTomato; Cd4-CreERT2 mice.

Fig.2 Detection of tdTomato expression in CD8+ T in spleen, blood and thymus of HE R26-CAG-LSL-tdTomato; Cd4-CreERT2 mice.
Fig.3 CreERT2 mediated recombination in colon of Cd4CreERT2/+; Rosa26tdTomato/+ mouse.

Fig.4 Detection of tdTomato(red) in various tissues of Cd4CreERT2/+; Rosa26tdTomato/+ mouse. Tissues with expression: Spleen, liver, lung, reproductive system, large intestine, small intestine, thymus, lymph node. No fluorescence expression detected: Brain, pancreas. (52-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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