Fig 1. Cre-mediated recombination in bone of Prg4CreERT2-EGFP/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) and GFP (green) in various tissues of Prg4CreERT2-EGFP/+; Rosa26tdTomato/+ mice. Expression tissues include: liver, bone, spleen, muscle, hair follicle. A few cells expressed in heart, salivary gland, adrenal gland, small intestine, testis. Tissues that unexpressed include brain, spinal cord, retina, lung, stomach, brown fat, kidney, colon, pancreas, thymus, pituitary. (37-day old, male)
TdTomato labeling was observed in tissue sections of Prg4CreERT2-EGFP/+;Rosa26tdTomato/+ untreated treated groups, indicating spontaneous Cre activity in the absence of tamoxifen.
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