Slco1c1-2A-CreERT2

品系全名

C57BL/6JSmo-Slco1c1em1(2A-CreERT2)Smoc

目录号

NM-KI-200262

品系状态

活体

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基因信息

基因名
Slco1c1

品系描述

将2A-CreERT2插入到小鼠Slco1c1基因终止密码子处。 SLCO1C1(溶质载体有机阴离子转运蛋白家族成员1C1)在甲状腺激素代谢中是必不可少的,甲状腺素 (T4) 由其转运到成人大脑中,再由 T4 转化为 3,5,3'-三碘甲状腺原氨酸 (T3)。在成人中,SLCO1C1 在两种脑屏障结构中表达:血脑屏障 (BBB) 和脉络丛,也在大脑的皮层和海马等的神经元表达。与报告小鼠交配的双阳性小鼠,在他莫昔芬诱导后,永久标记SLCO1C1 阳性细胞。可用于脑缺血、脑梗等研究。
应用领域:脑缺血,脑梗

验证数据

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图1 经他莫昔芬诱导后,tdtomato表达在Slco1c1-2A-CreERT2; Rosa26-tdTomato小鼠脉络丛和部分脑细胞中。

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图2 经他莫昔芬诱导后,tdtomato还会在视网膜和肌肉中出现信号;而其他组织包括垂体、心脏、肺、胃、颌下腺、棕色脂肪、肾、胰腺、小肠和大肠、脾、皮肤、卵巢和子宫均未检测到阳性信号。(想要获取更多信息需联系技术人员)


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