Dmd-Q995X
品系全名
C57BL/6JSmo-Dmdem1(Q995X)Smoc
目录号
NM-KI-18026
品系状态
活体
基因信息
基因名
Dmd
品系描述
疾病预测
Duchenne Muscular Dystrophy
验证数据
图1 Western blot 检测小鼠肌肉和心脏中Dystrophin的表达。点突变小鼠中检测不到 Dystrophin，而在野生型小鼠中可以检测到，说明该点突变造成了Dystrophin蛋白不表达。
图2 HE染色显示MDX小鼠(雄性，6月龄)骨骼肌肌间隙变宽，肌纤维大小不一，细胞核聚集，炎性细胞浸润。
图3 MDX小鼠的肢体抓力测试。
通过握力计（BIO-G53，Bioseb，France）进行MDX小鼠(雄性，6月龄)肢体强度的评估。 使MDX小鼠抓住拉杆然后轻轻向后拉，在失去抓地力之前施加到杆上的力被记录为峰值阻力（以克表示）。
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