Trp53-KO(2)

品系全名

C57BL/6JSmo-Trp53em5Smoc

目录号

NM-KO-191203

品系状态

胚胎冻存

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基因信息

基因名
Trp53

基因曾用名

bbl; bfy; bhy; p44; p53; Tp53

NCBI ID

22059

MGI ID

98834

Ensembl ID

ENSMUSG00000059552

Pubmed

Trp53

人类同源基因

TRP53

品系描述

敲除Trp53基因exon 5-7，建立Trp53基因敲除小鼠模型。
应用领域：肿瘤研究

疾病预测

Li-Fraumeni综合征
Li-Fraumeni Syndrome

近似模型的表型

MGI:2174783

参考文献

Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA, Tumor spectrum analysis in p53-mutant mice. Curr Biol. 1994 Jan 1;4(1):1-7

Li-Fraumeni综合征
Li-Fraumeni Syndrome

近似模型的表型

MGI:3584464

参考文献

Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T, Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60

恶性星形细胞瘤
Malignant Astrocytoma

近似模型的表型

MGI:5286078
注：该品系需与Nf1-KO(NM-KO-210301)交配才可能获得预期表型

参考文献

Reilly KM, Loisel DA, Bronson RT, McLaughlin ME, Jacks T, Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet. 2000 Sep;26(1):109-13

弥漫性大B细胞淋巴瘤
Diffuse Large B-Cell Lymphoma

近似模型的表型

MGI:5014832

参考文献

Slatter TL, Hung N, Campbell H, Rubio C, Mehta R, Renshaw P, Williams G, Wilson M, Engelmann A, Jeffs A, Royds JA, Baird MA, Braithwaite AW, Hyperproliferation, cancer, and inflammation in mice expressing a Delta133p53-like isoform. Blood. 2011 May 12;117(19):5166-77

神经纤维瘤病
Neurofibromatosis

近似模型的表型

MGI:3580069
注：该品系需与Nf1-KO(NM-KO-210301)交配才可能获得预期表型

参考文献

Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF, Mouse tumor model for neurofibromatosis type 1. Science. 1999 Dec 10;286(5447):2176-9

髓母细胞瘤
Medulloblastoma

近似模型的表型

MGI:3710320
注：该品系需与Cdkn2C-KO(NM-KO-2114003)交配才可能获得预期表型

参考文献

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF, The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev. 2005 Nov 15;19(22):2656-67

髓母细胞瘤
Medulloblastoma

近似模型的表型

MGI:3818748
注：该品系需与Rag1-KO(NM-KO-2103089)和Xrcc5-KO(NM-KO-202153)交配才可能获得预期表型

参考文献

Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P, Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene. 2006 Nov 16;25(54):7159-65

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