Cdkn2b-KO(p15-KO)

品系全名

C57BL/6JSmo-Cdkn2Bem1Smoc

目录号

NM-KO-190621

品系状态

胚胎冻存

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基因信息

基因名
Cdkn2b

品系描述

敲除Cdkn2b基因exon 2,建立Cdkn2b基因敲除小鼠模型。
应用领域:该基因与肿瘤抑制基因CDKN2A相邻,该区域在多种肿瘤中经常发生突变和缺失。该基因编码一种依赖于周期蛋白的激酶抑制剂,该抑制剂与CDK4或CDK6形成复合物,并阻止CDK激酶的激活,因此编码的蛋白起着细胞生长调节剂的作用,控制细胞周期G1的进展。

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