Cd36-KO

品系全名

C57BL/6JSmo-Cd36em1Smoc

目录号

NM-KO-190771

品系状态

活体

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基因信息

基因名
Cd36

基因曾用名

FAT; GPIV; Scarb3

NCBI ID

12491

MGI ID

107899

Ensembl ID

ENSMUSG00000002944

Pubmed

Cd36

人类同源基因

CD36

品系描述

敲除Cd36基因exon 5-9，建立Cd36基因敲除小鼠模型。
应用领域：该基因编码的蛋白具有重要的细胞黏附分子功能,该基因的突变导致血小板糖蛋白缺乏。

疾病预测

血小板型出血性疾病 10
Platelet-Type Bleeding Disorder 10

近似模型的表型

MGI:3587412

参考文献

Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF , Silverstein RL, A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem. 1999 Jul 2;274(27):19055-62

发表文献 3篇

1. CD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease
发表年份：2024 来源杂志：METABOLISM-CLINICAL AND EXPERIMENTAL

2. Thrombospondin 1 improves hepatic steatosis in diet-induced insulinresistant mice and is associated with hepatic fat content in humans
发表年份：2020-07-21 来源杂志：Elseiver Sciense

3. Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans
发表年份：2020 来源杂志：EBioMedicine

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