Trem2-KO

品系全名

C57BL/6JSmo-Trem2em1Smoc

目录号

NM-KO-190402

品系状态

活体

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基因信息

基因名
Trem2

基因曾用名

TREM-2; Trem2a; Trem2b; Trem2c

NCBI ID

83433

MGI ID

1913150

Ensembl ID

ENSMUSG00000023992

Pubmed

Trem2

人类同源基因

TREM2

品系描述

敲除Trem2基因的exon2-3 区域，获得Trem2基因敲除小鼠模型。
应用领域：免疫相关

发表文献 11篇

1. TREM2+ macrophages confers post-infarction cardioprotection by restraining ROS via NLRP3 inflammasome
发表年份：2026 来源杂志：BIOCHEMICAL PHARMACOLOGY

2. TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury
发表年份：2026 来源杂志：CNS Neuroscience & Therapeutics

3. TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, leading to anxiety-like behaviors
发表年份：2026 来源杂志：JOURNAL OF ALZHEIMERS DISEASE

4. High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironment
发表年份：2025 来源杂志：EBioMedicine

5. TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis
发表年份：2025 来源杂志：Journal of Neuroinflammation

6. TREM2 Modulates Postoperative Cognitive Function in Aged Mice by Inhibiting the NLRP3/caspase-1 Pathway and Apoptosis via PLCγ2 Activation
发表年份：2025 来源杂志：MOLECULAR NEUROBIOLOGY

7. Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma
发表年份：2024 来源杂志：Theranostics

8. TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36
发表年份：2024 来源杂志：Cell Death & Disease

9. TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma
发表年份：2023-03-06 来源杂志：JOURNAL OF HEPATOLOGY

10. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment
发表年份：2023 来源杂志：Cell Death & Disease

11. Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner
发表年份：2022 来源杂志：Journal of Advanced Research

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