Ceacam16-KO

品系全名

C57BL/6Smoc-Ceacam16em1Smoc

目录号

待定

品系状态

在研

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品系描述

敲除Ceacam16基因exon 1-2，建立Ceacam16基因敲除小鼠模型。

疾病预测

常染色体显性遗传非综合征性耳聋4A
Autosomal Dominant Nonsyndromic Deafness 4A

近似模型的表型

MGI:5437687

参考文献

Kammerer R, Ruttiger L, Riesenberg R, Schauble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR, Zimmermann W, Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. J Biol Chem. 2012 Jun 22;287(26):21584-98

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