Cd274-KO(2)

品系全名

C57BL/6JSmo-Cd274em2Smoc

目录号

NM-KO-18044

品系状态

活体

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基因信息

基因名
Cd274

品系描述

Cd274基因也叫B7-H1, Pdcd1lg1, PD-L1。通过敲除Cd274基因的exon 3-5区域,获得Cd274-KO(2)基因敲除小鼠模型。该品系曾用名为:Pd-l1-KO(2)。
应用领域:炎症、免疫等

验证数据

image.png

图1. FACS检测PD-L1基因敲除纯合子、杂合子以及野生型小鼠中腹腔巨噬细胞、脾脏细胞和骨髓细胞中PD-L1的表达。结果显示在PD-L1基因敲除纯合子中几乎检测不到表达,证明该小鼠的PD-L1基因已被完全敲除。


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