Cdkn2a-Flox(p16/p19-Flox)

MGI:4418448
注：该品系与Pten-Flox(NM-CKO-18004)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

MGI:4418449
注：该品系与Ctnnb1-Flox(NM-CKO-200154)，Pten-Flox(NM-CKO-18004)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

MGI:5603215
注：该品系与Tyr-cre/ERT工具鼠交配才可能获得预期表型

Huijbers IJ, Krimpenfort P, Chomez P, van der Valk MA, Song JY, Inderberg-Suso EM, Schmitt-Verhulst AM, Berns A, Van den Eynde BJ, An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 2006 Mar 15;66(6):3278-86

MGI:5441554
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L, Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol. 2012 Aug;227(4):417-30

MGI:2687217
注：该品系与Kras-LSL-G12D(NM-KI-190003)和Pdx1-cre工具鼠交配才可能获得预期表型

Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA, Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003 Dec 15;17(24):3112-26

MGI:5308951
注：该品系与Kras-LSL-G12D(NM-KI-190003)，P53-Flox(2)(NM-CKO-190067)和Pdx1-cre工具鼠交配才可能获得预期表型

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA, Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52

MGI:5792147
注：该品系与Nf1-Flox(NM-CKO-200018)和Ad-Cre工具鼠交配才可能获得预期表型

Dodd RD, Mito JK, Eward WC, Chitalia R, Sachdeva M, Ma Y, Barretina J, Dodd L, Kirsch DG, NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. Mol Cancer Ther. 2013 Sep;12(9):1906-17

MGI:5752235
注：该品系与Nras-Flox(NM-CKO-2100519)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29

MGI:5752239
注：该品系与Nras-Flox(NM-CKO-2100519)，Stk11-Flox(2)(NM-CKO-200251)和Tyr-cre/ERT2工具鼠交配才可能获得预期表型

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29