Cd45.1

品系全名

C57BL/6JSmo-Ptprcem1(K302E)Smoc

目录号

NM-KI-210226

品系状态

活体

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基因信息

基因名
Ptprc

基因曾用名

loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4

NCBI ID

19264

MGI ID

97810

Ensembl ID

ENSMUSG00000026395

Pubmed

Ptprc

人类同源基因

PTPRC

品系描述

将小鼠Ptprc基因302位由K替换为E，建立该Ptprc基因点突变小鼠模型。

验证数据

1.png

图1. 流式检测Cd45.1杂合子小鼠外周血中CD45.1的表达。结果显示：Cd45.1杂合子小鼠外周血中可以检测到CD45.1的显著表达，符合预期。


2.png

图2. 流式检测Cd45.1杂合子小鼠脾脏中CD45.1的表达。结果显示：Cd45.1杂合子小鼠脾脏中可以检测到CD45.1的显著表达，符合预期。

image.png

Fig.3 Detection of CD45.1 expression on CD45+ cells in blood of WT C57BL/6 mice and CD45.1 mice by FACS. Leukocytes were collected from wild-type C57BL/6 mice (male, 8 weeks old) and HO CD45.1 mice (male, 8 weeks old), and analyzed by flow cytometry with anti-mCD45.1 and anti-CD45.2. CD45.1 was exclusively detectable on CD45+ cells in HO CD45.1 mice but not in wild-type mice, whereas CD45.2 was exclusively detectable on CD45+ cells in wild-type C57BL/6 mice but not in HO CD45.1 mice.

发表文献 5篇

1. Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury
发表年份：2024 来源杂志：Cell Stem Cell

2. RNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1
发表年份：2024 来源杂志：Nature Communications

3. Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway
发表年份：2024 来源杂志：Theranostics

4. IKKβ increases neuropilin-2 and promotes the inhibitory function of CD9+ Bregs to control allergic diseases
发表年份：2022 来源杂志：PHARMACOLOGICAL RESEARCH

5. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
发表年份：2021-11-17 来源杂志：iScience

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