Nf1-Flox/Dhh-Cre

品系全名

C57BL/6Smoc-Nf1tm1(flox)Dhhem(Kozak-Cre-WPRE-pA)1Smoc

目录号

NM-XA-242545

品系状态

胚胎冻存

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基因信息

基因名
Nf1

基因曾用名

Dsk9; Nf-1; AW494271; Mhdadsk9; E030030H24Rik

染色体位置

11

NCBI ID

18015

MGI ID

97306

Ensembl ID

ENSMUSG00000020716

Pubmed

Nf1

人类同源基因

NF1

品系描述

The Nf1-Flox(NM-CKO-200018) was crossed with Dhh-Cre(NM-KI-225049) to generate Nf1-Flox/Dhh-Cre mice.

验证数据

image.png

Fig.1 Nf1Flox/Flox; Dhh-Cre Spontaneous Neurofibroma Phenotypic Analysis. 

Body weight change (A), Percent survival (B) and Representative image (C) of Nf1Flox/Flox; Dhh-Cre mice and C57BL/6 mice.

The results showed that death began to occur in Nf1Flox/Flox; Dhh-Cre mice on postnatal day 245, with a median survival of 310 days (including mice that were euthanized), and in all Nf1Flox/Flox; Dhh-Cre mice, coat color transitioned from black to brownish-yellow starting on postnatal day 94 and gradually deepened.

Note. 7 male, 5 female. Date of birth: 2024/10/15.

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