hACE2

Fig1. Analysis of ACE2 expression profile by qPCR in the ACE2 humanized mice. The homozygous and heterozygous KI mice express human ACE2 in lung, kidney and small intestine; while the heterozygous KI mice and wild type express mouse Ace2 on heart, lung, kidney and small intestine.

Fig2. Analysis of ACE2 gene expression in the lungs by RT-PCR in WT and ACE2 humanized mice. Mouse Ace2 mRNA was detectable by P7/8(446bp), human ACE2 mRNA was detectable by P5/6(283bp), M:100bp Plus DNA ladder from Transgen (BM311). The homozygous KI mouse expresses human ACE2 in the lungs, while the heterozygous KI mouse expresses both human ACE2 and mouse Ace2.

The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice
来源杂志：International Journal of Molecular Sciences