Foxl1-2A-CreERT2

A 2A-CreERT2 coexpression cassette is inserted before the stop codon of mouse Foxl1 gene via homologous recombination to establish a Foxl1-CreERT2 recombinase tool stain. This strain can be used to knockout target gene inFoxl1+ cells after tamoxifen treatment when crossed with flox mice.

Fig 1. CreERT2-mediated recombination in small intestine of Foxl1CreERT2/+; Rosa26tdTomato/+ mice.

Fig 2. Detection of tdTomato (red) in various tissues of Foxl1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: small intestine, colon， stomach,lung, kidney, ovary. A few cells expressed in brain, adrenal gland, muscle, thymus. Tissues that unexpressed include retina, liver, salivary glands, brown fat, pancreas, spleen, skin. (4.5-month old, female) (For more detailed information please contact our technical advisor.)