hIGF1R(2)

品系全名

C57BL/6Smoc-Igf1rtm(hIGF1R)Smoc

目录号

NM-HU-230053

品系状态

活体

导出PDF

基因信息

基因名
Igf1r

品系描述

The endogenous mouse Igf1r gene was replaced by human IGF1R gene.

验证数据

image.png

Fig.1 Detection of human IGF1R expression in female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr. M, marker; WT, wild type; HO, Homozygous.

image.png

Fig.2 Detection of hIGF1R expression in the lung of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of hIGF1R expression in the brain of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.4 Detection of hIGF1R expression in the kidney of female homozygous hIGF1R(2) knockin mice. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.5 Detection of lymphcytes subsets in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.6 Detection of myeloid cells in the spleen of female hIGF1R(2) knockin mice by FACS. (n=3 in both groups, 7-week-old WT mice and 6-week-old hIGF1R mice)

Abbr.  WT, wild type; HO, homozygous.


你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式,包括基因定点修饰的小鼠命名,比如:敲除、敲入、点突变等等,和随机转基因的小鼠命名。

查看