Isl1-Cre
品系全名
C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc
目录号
NM-KI-200126
品系状态
精子冻存
基因信息
基因名
Isl1
品系描述
验证数据

Fig. 1 Cre-mediated recombination in the retina of IslCreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer (RGC) and inner nuclear layer (INL) of IslCre/+; Rosa26tdTomato/+ mouse.

Fig. 2 Cre-mediated recombination in the pancreas of IslCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar cells and islet cells derived from IslCre/+; Rosa26tdTomato/+ mouse.

Fig. 3 Detection of tdTomato(red) in various tissues of IslCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the retina, pancreas, heart, brain, pituitary gland, lung, liver, stomach, submandibular gland, brown fat, kidney, intestine, colon, spleen, thymus, testis and epididymis. (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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