Eno2-2A-CreERT2
品系全名
C57BL/6Smoc-Eno2em1(2A-CreERT2)Smoc
目录号
NM-KI-200011
品系状态
精子冻存
基因信息
基因名
Eno2
品系描述
A 2A-CreERT2 expression cassette was knocked into the Eno2 gene stop codon site.
应用领域：Eno2-2A-CreERT2 mice express the tamoxifen inducible creERT2 in the nervous system. CreERT2 mediated recombination can also be detected in the muscle.
*使用本品系发表的文献需注明: Eno2-2A-CreERT2 mice (Cat. NO. NM-KI-200011) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig. 1 CreERT2-mediated recombination in the brian of Eno2CreERT2/+; Rosa26tdTomato/+ mouse.
Detection of tdTomato (red) in the brian of Eno2CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.
Fig. 2: Detection of tdTomato in various tissues of Eno2CreERT2/+; Rosa26tdTomato/+ mice. CreERT2 mediated recombination can be detected in the brain. Some leakiness were detected in the muscle. (For more detailed information please contact our technical advisor.)
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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