Ccr2-KO

品系全名

C57BL/6Smoc-Ccr2em1Smoc

目录号

NM-KO-190018

品系状态

活体

导出PDF

基因信息

基因名
Ccr2

基因曾用名

Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

染色体位置

9

NCBI ID

12772

MGI ID

106185

Ensembl ID

ENSMUSG00000049103

Pubmed

Ccr2

人类同源基因

CCR2

品系描述

This Ccr2 knockout mouse model was generated by knocking out the exon 3 region of the Ccr2 .
应用领域：Immune-related

验证数据

image.png

Fig1. Validation of Ccr2 gene expression by RT-PCR.(A) Schematic diagram of primer design; (B) No product was obtained from Ccr2 knockout homozygous mice, and the wild-type mice could obtain the 824bp target PCR product. (M, DNA marker; HO, homozygous; WT, wild type)


image.png

Fig2. Validation of  CCR2 expression in the bone marrow by FACS. CCR2 expression could not be detected on CD11b+ cells of the Ccr2 knockout homozygous mice. 


image.png

Fig3. Validation of CCR2 expression in the spleen by FACS. CCR2 expression could not be detected on CD11b+ cells of the Ccr2 knockout homozygous mice. 

发表文献

The Effect of Lymphangiogenesis in Transplant Arteriosclerosis
来源杂志：Circulation

你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和随机转基因的小鼠命名。

查看