Tnfrsf1a/Tnfrsf1b-KO

品系全名

C57BL/6JSmo-Tnfrsf1aem1Tnfrsf1bem1Smoc

目录号

NM-KO-18036

品系状态

胚胎冻存

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品系描述

This strain is also called p55/p75-KO. The Tnfrsf1a and Tnfrsf1b double knockout mouse models were obtained by knocking out both exon 2-5 region of mouse Tnfrsf1a gene and exon2 of mouse Tnfrsf1b gene. Tnfrsf1a and Tnfrsf1b deletion (p55 and p75 deficiency) homozygous mice are viable and fertile, and these homozygous mice fail to bind TNF (tumor necrosis factor).

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