hFCRN
品系全名
C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
目录号
NM-HU-00109
品系状态
胚胎冻存
基因信息
基因名
Fcgrt
品系描述
This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.
应用领域：cancer research,Immunotherapy,drug screening
*使用本品系发表的文献需注明: hFCRN mice (Cat. NO. NM-HU-00109) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1.The expression of mouse FCGRT and human FCGRT in liver was confirmed by western blotting.（Data is sourced from collaborator.）
Fig2. PK validation of human antibody (ustekinumab and briakinumab) in FCGRT humanized Mice.（Data is sourced from collaborator.）
发表文献
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