Alb-CreERT2
品系全名
B6.129S-Albtm1.1(CreERT2)Smoc
目录号
NM-KI-00002
品系状态
活体
基因信息
基因名
ALB
品系描述
Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.
应用领域：cre-mediated recombination system
*使用本品系发表的文献需注明: Alb-CreERT2 mice (Cat. NO. NM-KI-00002) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1 X-gal staining of liver slides of Alb-CreERT2 and LacZ positive mouse before and after tamoxifen injection.
Fig2 Immunofluorescence analysis of liver using anti-Alb(Green) and anti-LacZ(Red) antibodies showed that Cre is expressed in most hepatocytes.
Fig3 Blood biochemical assay of Alb-CreERT2 male and female mice. Alb-CreERT2 mice do not display any liver functional abnormalities.
发表文献
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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