Camk2a-IRES-Cre(SD)

品系全名

SD-Camk2aem1(IRES-iCre)Smoc

目录号

NR-KI-190004

品系状态

胚胎冻存

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基因信息

基因名
Camk2a

基因曾用名

PKCCD; PK2CDD

染色体位置

18

NCBI ID

25400

RGD ID

2261

Ensembl ID

ENSRNOG00000018712

Pubmed

Camk2a

人类同源基因

CAMK2A

品系描述

利用CRISPR基因编辑技术，将IRES-iCre共表达结构插入到大鼠Camk2a基因终止密码子处。
应用领域：Cre工具鼠

验证数据

Camk2a-(iCre).png


Figure 1: 大鼠脑部EGFP和tdTomato的表达情况检测。

Rosa26Loxp-tdTomato-3xpolyA-Loxp-EGFP/+大鼠，可在脑部检测到tdTomato的表达，证明R26-(Loxp-tdTomato-3xpolyA-Loxp-EGFP)转基因大鼠可以作为荧光报告大鼠使用；而Camk2aiCre/+; Rosa26Loxp-tdTomato-3xpolyA-Loxp-EGFP/+双转基因鼠，可在脑部检测到EGFP的表达，证明Camk2a-(iCre)大鼠可以成为实现Camk2a阳性细胞特异性敲除或表达的工具鼠。

Camk2a-Cre.png

Figure ２: 大鼠脑部细胞EGFP和tdTomato的表达情况检测。


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