模型资源
M-NSG
品系全名
NOD.Cg-PrkdcscidIl2rgem1Smoc
目录号
NM-NSG-001
品系状态
活体
基因信息
基因名
IL2RG
基因曾用名
gc; p64; [g]c; CD132; gamma(c)
NCBI ID
MGI ID
Ensembl ID
Pubmed
人类同源基因
IL2RG
品系描述
验证数据
表型分析
T、B、NK 细胞 FACS 检测

图 1.M-NSG 小鼠脾脏中 T、B 和 NK 细胞缺失。取 BALB/c、NOD-scid 和 M-NSG 小鼠的脾脏细胞,通过 FACS 对其中 T、B 和 NK 细胞的组成进行分析 (A) 并进行统计对比 (B)。

图 2.M-NSG 小鼠血液中 T、B 和 NK 细胞缺失。取 BALB/c、NOD-scid 和 M-NSG 小鼠的外周血,通过 FACS 对其中 T、B 和 NK 细胞的组成进行分析 (A) 并进行统计对比 (B)。
M、MΦ、DC 细胞 FACS 检测

图 3.M-NSG 小鼠脾脏中单核细胞、巨噬细胞和 DC 细胞比例。取 BALB/c、NOD-scid 和 M-NSG 小鼠的脾脏细胞,通过 FACS 对其中单核细胞、巨噬细胞和 DC 细胞的组成进行分析 (A) 并进行统计对比 (B)。

图 4.M-NSG 小鼠外周血中单核细胞、巨噬细胞和 DC 细胞比例。取 BALB/c、NOD-scid 和 M-NSG 小鼠的外周血,通过 FACS 对其中单核细胞、巨噬细胞和 DC 细胞的组成进行分析 (A) 并进行统计对比 (B)。

图5. M-NSG小鼠生长曲线(n=600)

图6. M-NSG小鼠血清抗体亚类检测(雄性,8周龄)。

图7. M-NSG 各组织病理学检测。A:除脾脏和胸腺外,其他组织未见明显异常,包括:脑、视网膜、脊髓、心脏、肝、肺、肾、小肠、大肠、胃、唾液腺、胰腺、卵巢、子宫、睾丸、附睾、骨骼肌、皮肤和棕色脂肪(雌性,6周龄);B,C: M-NSG小鼠的脾脏缺乏白髓,淋巴细胞减少(6周龄)。
表1. M-NSG小鼠血常规检测

表2. M-NSG小鼠血生化检测

CDX/PDX成瘤及药效验证

图8. A549 肺肿瘤细胞(A)或 Raji 淋巴瘤细胞(B)在 M-NSG 小鼠上的成瘤验证。
基于 M-NSG 小鼠成功建立的 CDX 模型

图9.利用淋巴癌(Raji)CDX模型进行抗人CD47抗体药效验证实验。

图10. 利用肺癌(A549)CDX模型进行CAR-T药效验证实验。

图11. 移植CAR-T的M-NSG小鼠体内的GVHD研究。

图12. 肝癌PDX在 M-NSG 小鼠上的成瘤验证。
人源免疫系统重建模型
利用重度免疫缺陷M-NSG小鼠可以通过移植人源外周血细胞、造血干细胞等,实现在小鼠体内重塑人源免疫系统,为免疫学、肿瘤学及人类传染疾病等研究提供有力工具。
PBMC人源化小鼠

Hu-PBMC模型,或者被称为Hu-PBL(perihperal blood lymphocyte, PBL)模型,是一种构建较为简单和经济的免疫系统人源化小鼠模型。Hu-PBMC模型的移植方式主要有腹腔注射与尾静脉注射,通常以4-6周龄的M-NSG小鼠作为移植受体,PBMC移植/接种量通常在5~10*10^6/小鼠。该模型常被用于研究人效应T细胞的活化以及评估免疫抑制药物。
Hu-PBMC模型的供体筛选

图13. M-NSG小鼠中进行Hu-PBMC重建的供体筛选。
图14.流式分析Hu-PBMC模型外周血淋巴细胞亚群。将人PBMCs(5E6)静脉注射M-NSG小鼠(雌性,6-8周龄,n=4)。植入human PBMCs后取不同时间点的小鼠血液进行流式细胞分析。
图15. 利用骨髓瘤(H929)Hu-PBMC模型进行体内药效研究。

图16. 利用乳腺癌(MDA-MB-231)Hu-PBMC模型进行体内药效研究。
HSC人源化小鼠

Hu-HSC模型,也叫hu-CD34+,或叫hu-SRC(scid-repopulatingcell),已经被广泛应用于研究人类造血发育、细胞介导的免疫反应以及HIV和EBV等病毒感染性疾病中。 其构建方式是将来自人脐带血、骨髓、G-CSF激活的外周血或胎肝的人CD34+ HSCs通过静脉内(i.v.)或股骨内(i.f.)注射到成年免疫缺陷小鼠M-NSG中,得到的小鼠可以产生多种造血干细胞。
图17. M-NSG小鼠中进行Hu-HSC重建的供体筛选。

图18. 流式分析Hu-HSC模型外周血淋巴细胞亚群。

图19. 利用乳腺癌(MDA-MB-231)Hu-HSC模型进行体内药效研究。
发表文献 145篇
1.
Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy
发表年份:2025
来源杂志:Signal Transduction and Targeted Therapy
2.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
发表年份:2025
来源杂志:NATURE
3.
Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant Glioma
发表年份:2025
来源杂志:Advanced Science
4.
JMJD3 upregulates ALOX5 to drive malignancy and concomitant ferroptosis sensitivity in gastric cancer
发表年份:2025
来源杂志:Cell Death & Disease
5.
Low SVEP1 in intrahepatic cholangiocarcinoma mediates phenotype switching-driven metastasis by Jag2/Notch1/Hes5
发表年份:2025
来源杂志:Cell Death & Disease
6.
Preclinical Development and a Case Report of a Nanobody-Based CLDN18.2 CAR-T IMC002 with Reduced On-Target Off-Tumor Toxicity
发表年份:2025
来源杂志:MOLECULAR CANCER THERAPEUTICS
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A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer
发表年份:2025
来源杂志:Nature Nanotechnology
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CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA
发表年份:2025
来源杂志:Molecular Cancer
9.
Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming
发表年份:2025
来源杂志:Cell Metabolism
10.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation
发表年份:2025
来源杂志:Cell Metabolism
11.
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses
发表年份:2025
来源杂志:Nature Biomedical Engineering
12.
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
发表年份:2025
来源杂志:IMMUNITY
13.
Clinical functional proteomics of intercellular signalling in pancreatic cancer
发表年份:2024
来源杂志:NATURE
14.
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
发表年份:2024
来源杂志:CANCER CELL
15.
Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
发表年份:2024
来源杂志:NATURE MATERIALS
16.
An oncolytic virus–T cell chimera for cancer immunotherapy
发表年份:2024
来源杂志:NATURE BIOTECHNOLOGY
17.
The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma
发表年份:2024
来源杂志:Cancer Discovery
18.
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
发表年份:2024
来源杂志:Cell Metabolism
19.
Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
发表年份:2024
来源杂志:Cell Metabolism
20.
A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway
发表年份:2024
来源杂志:Molecular Cancer
21.
Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors
发表年份:2024
来源杂志:ADVANCED MATERIALS
22.
An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity
发表年份:2024
来源杂志:ADVANCED MATERIALS
23.
Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone
发表年份:2024
来源杂志:Nature Biomedical Engineering
24.
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
发表年份:2024
来源杂志:Cell Stem Cell
25.
FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
发表年份:2024
来源杂志:Nature Communications
26.
Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
发表年份:2024
来源杂志:Nature Communications
27.
PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
发表年份:2024
来源杂志:Nature Communications
28.
Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy
发表年份:2024
来源杂志:Nature Communications
29.
Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice
发表年份:2024
来源杂志:Nature Communications
30.
Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity
发表年份:2024
来源杂志:Nature Communications
31.
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
发表年份:2024
来源杂志:Nature Communications
32.
Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies
发表年份:2024
来源杂志:Nature Communications
33.
ATP6V1D drives hepatocellular carcinoma stemness and progression via both lysosome acidification-dependent and -independent mechanisms
发表年份:2024
来源杂志:Autophagy
34.
Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis
发表年份:2024
来源杂志:Advanced Science
35.
Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development
发表年份:2024
来源杂志:Advanced Science
36.
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer
发表年份:2024
来源杂志:Advanced Science
37.
SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis
发表年份:2024
来源杂志:Advanced Science
38.
A pan-KRAS degrader for the treatment of KRAS-mutant cancers
发表年份:2024
来源杂志:Cell Discovery
39.
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
发表年份:2024
来源杂志:LEUKEMIA
40.
Anagrelide and idarubicin combination induces GSDME-mediated pyroptosis as a potential therapy for high-PDE3A acute myeloid leukemia
发表年份:2024
来源杂志:LEUKEMIA
41.
Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
发表年份:2024
来源杂志:CANCER RESEARCH
42.
Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma
发表年份:2024
来源杂志:CANCER RESEARCH
43.
Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia
发表年份:2024
来源杂志:CANCER RESEARCH
44.
HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
发表年份:2024
来源杂志:Theranostics
45.
Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease
发表年份:2024
来源杂志:Gut Microbes
46.
Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia
发表年份:2024
来源杂志:Cell Reports Medicine
47.
Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
48.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia
发表年份:2024
来源杂志:Journal of Advanced Research
49.
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies
发表年份:2024
来源杂志:Journal of Advanced Research
50.
Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
51.
LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
发表年份:2024
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
52.
iPSC-derived NK cells with site-specific integration of CAR19 and IL24 at the multi-copy rDNA locus enhanced antitumor activity and proliferation
发表年份:2024
来源杂志:MedComm
53.
Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy
发表年份:2024
来源杂志:JOURNAL OF NANOBIOTECHNOLOGY
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RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
55.
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
56.
ImmunoPET imaging of LAG-3 expression in tumor microenvironment with 68Ga-labelled cyclic peptides tracers: from bench to bedside
发表年份:2024
来源杂志:Journal for ImmunoTherapy of Cancer
57.
Restoring T and B cell generation in X-linked severe combined immunodeficiency mice through hematopoietic stem cells adenine base editing
发表年份:2024
来源杂志:MOLECULAR THERAPY
58.
Mid1 promotes synovitis in rheumatoid arthritis via ubiquitin-dependent post-translational modification
发表年份:2024
来源杂志:PHARMACOLOGICAL RESEARCH
59.
miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair
发表年份:2024
来源杂志:JACC-Basic to Translational Science
60.
Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis
发表年份:2024
来源杂志:International Journal of Biological Sciences
61.
LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma
发表年份:2024
来源杂志:Cell Death & Disease
62.
Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation
发表年份:2024
来源杂志:Cell Death & Disease
63.
Small extracellular vesicle piR-hsa-30937 derived from pancreatic neuroendocrine neoplasms upregulates CD276 in macrophages to promote immune evasion
发表年份:2024
来源杂志:Cancer Immunology Research
64.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
发表年份:2024
来源杂志:Cell Reports
65.
Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation
发表年份:2024
来源杂志:Stem Cell Research & Therapy
66.
Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation
发表年份:2024
来源杂志:PHYTOMEDICINE
67.
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
发表年份:2024
来源杂志:OncoImmunology
68.
PHE1-based IgG-like antibody platform provides a novel strategy for enhanced T-cell immunotherapy
发表年份:2024
来源杂志:Frontiers in Immunology
69.
INPP4B suppresses HER2-induced mesenchymal transition in HER2+ breast cancer and enhances sensitivity to Lapatinib
发表年份:2024
来源杂志:BIOCHEMICAL PHARMACOLOGY
70.
The CDK4/6 inhibitor Palbociclib synergizes with ATRA to induce differentiation in AML
发表年份:2024
来源杂志:MOLECULAR CANCER THERAPEUTICS
71.
TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B-cell lymphomas
发表年份:2024
来源杂志:LIFE SCIENCES
72.
FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis
发表年份:2024
来源杂志:Communications Biology
73.
IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer
发表年份:2024
来源杂志:INTERNATIONAL IMMUNOPHARMACOLOGY
74.
ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer
发表年份:2024
来源杂志:Translational Oncology
75.
HDAC inhibitors target IRS4 to enhance anti‑AR therapy in AR‑positive triple‑negative breast cancer
发表年份:2024
来源杂志:INTERNATIONAL JOURNAL OF ONCOLOGY
76.
Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model
发表年份:2024
来源杂志:EJNMMI Radiopharmacy and Chemistry
77.
Effective in vivo reactivation of HIV-1 latency reservoir via oral administration of EK-16A-SNEDDS
发表年份:2024
来源杂志:EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
78.
PLA2G2D promotes immune escape in non-small cell lung cancer by regulating T cell immune function through PD-L1-expressing extracellular vesicles
发表年份:2024
来源杂志:SCANDINAVIAN JOURNAL OF IMMUNOLOGY
79.
Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity
发表年份:2024
来源杂志:ACS Omega
80.
FYB1-targeted modulation of CAPG promotes AML progression
发表年份:2024
来源杂志:MOLECULAR AND CELLULAR BIOCHEMISTRY
81.
PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome
发表年份:2024
来源杂志:DNA AND CELL BIOLOGY
82.
Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice
发表年份:2024
来源杂志:Journal of Gastrointestinal Oncology
83.
Exosome-derived circCCAR1 promotes CD8+T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023-03-18
来源杂志:Molecular Cancer
84.
Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma
发表年份:2023-03-12
来源杂志:International Journal of Molecular Sciences
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A novel antidiuretic hormone governs tumour-induced renal dysfunction
发表年份:2023
来源杂志:NATURE
86.
Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals
发表年份:2023
来源杂志:CELL
87.
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
发表年份:2023
来源杂志:Signal Transduction and Targeted Therapy
88.
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
发表年份:2023
来源杂志:Molecular Cancer
89.
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
发表年份:2023
来源杂志:NATURE IMMUNOLOGY
90.
Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress
发表年份:2023
来源杂志:GASTROENTEROLOGY
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Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain
发表年份:2023
来源杂志:Cell Metabolism
92.
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
发表年份:2023
来源杂志:Cellular & Molecular Immunology
93.
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
发表年份:2023
来源杂志:NATURE CELL BIOLOGY
94.
Cyclosporine A-resistant CAR-T cells mediate antitumour immunity in the presence of allogeneic cells
发表年份:2023
来源杂志:Nature Communications
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SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
发表年份:2023
来源杂志:Nature Communications
96.
Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
发表年份:2023
来源杂志:Nature Communications
97.
Sequence-based drug design as a concept in computational drug design
发表年份:2023
来源杂志:Nature Communications
98.
TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models
发表年份:2023
来源杂志:Nature Communications
99.
Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple-negative breast cancer to immune checkpoint inhibitors
发表年份:2023
来源杂志:Cancer Communications
100.
Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins
发表年份:2023
来源杂志:Cancer Communications
101.
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling
发表年份:2023
来源杂志:JOURNAL OF CLINICAL INVESTIGATION
102.
Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s
发表年份:2023
来源杂志:JOURNAL OF EXPERIMENTAL MEDICINE
103.
CAR-Aptamers Enable Traceless Enrichment and Monitoring of CAR-Positive Cells and Overcome Tumor Immune Escape
发表年份:2023
来源杂志:Advanced Science
104.
NIRF/PET imaging of γδ T cells via metabolic glycoengineering and bioorthogonal labeling
发表年份:2023
来源杂志:CHEMICAL ENGINEERING JOURNAL
105.
Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA-Seq
发表年份:2023
来源杂志:Advanced Science
106.
Targeted therapy of central nervous system acute lymphoblastic leukemia with an integrin α6-targeted self-assembling proapoptotic nanopeptide
发表年份:2023
来源杂志:Engineering
107.
Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis
发表年份:2023
来源杂志:Gut Microbes
108.
Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
发表年份:2023
来源杂志:LEUKEMIA
109.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability
发表年份:2023
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
110.
Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
发表年份:2023
来源杂志:CANCER RESEARCH
111.
PICH activates Cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer.
发表年份:2023
来源杂志:CANCER RESEARCH
112.
Faecalibacterium prausnitzii abrogates intestinal toxicity and promotes tumor immunity to increase the efficacy of dual CTLA-4 and PD-1 checkpoint blockade
发表年份:2023
来源杂志:CANCER RESEARCH
113.
Targeted glycan degradation potentiates cellular immunotherapy for solid tumors
发表年份:2023
来源杂志:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
114.
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia
发表年份:2023
来源杂志:Biomarker Research
115.
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer
发表年份:2023
来源杂志:JOURNAL OF NANOBIOTECHNOLOGY
116.
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response
发表年份:2023
来源杂志:HAEMATOLOGICA
117.
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022-07-26
来源杂志:nature communications
118.
A Chimeric Conjugate of Antibody and Programmable DNA Nanoassembly Smartly Activates T cell for Precise Cancer Cell Targeting
发表年份:2022-06-24
来源杂志:A Journal of the Gesellschaft Deutscher Chemiker
119.
BSA-AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma
发表年份:2022
来源杂志:ADVANCED MATERIALS
120.
Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy
发表年份:2022
来源杂志:Nature Biomedical Engineering
121.
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
发表年份:2022
来源杂志:Nature Communications
122.
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica
发表年份:2022
来源杂志:Nature Communications
123.
Modeling Human Thyroid Development by Fetal Tissue-Derived Organoid Culture
发表年份:2022
来源杂志:Advanced Science
124.
Inhibition of Calcium Signaling Prevents Exhaustion and Enhances Anti-Leukemia Efficacy of CAR-T Cells via SOCE-Calcineurin-NFAT and Glycolysis Pathways
发表年份:2022
来源杂志:Advanced Science
125.
Nano-Biohybrid DNA Engager That Reprograms the T-Cell Receptor
发表年份:2022
来源杂志:Journal of the American Chemical Society
126.
Therapeutic strategies targeting uPAR potentiate anti–PD-1 efficacy in diffuse-type gastric cancer
发表年份:2022
来源杂志:Science Advances
127.
Heliangin acts as a covalent ligand of RPS2 that disrupts pre-rRNA metabolic processes in NPM1-mutated acute myeloid leukemia
发表年份:2022
来源杂志:Acta Pharmaceutica Sinica B
128.
An armed oncolytic virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen-presenting cells in situ
发表年份:2022
来源杂志:MOLECULAR THERAPY
129.
Single-cell ATAC-seq maps the comprehensive and dynamic chromatin accessibility landscape of CAR-T cell dysfunction
发表年份:2022
来源杂志:LEUKEMIA
130.
FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer
发表年份:2022
来源杂志:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
131.
Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL
发表年份:2022
来源杂志:CELL DEATH AND DIFFERENTIATION
132.
Visualizing γδ T cells by very late antigen-4-targeted positron emission tomography
发表年份:2022
来源杂志:EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
133.
Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model
发表年份:2021-03-11
来源杂志:Front. Immunol
134.
Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis
发表年份:2021-01-08
来源杂志:Cancers
135.
Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
发表年份:2021
来源杂志:SCIENCE
136.
A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity
发表年份:2021
来源杂志:Science Translational Medicine
137.
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
发表年份:2021
来源杂志:MOLECULAR CELL
138.
CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase
发表年份:2021
来源杂志:HEPATOLOGY
139.
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression
发表年份:2021
来源杂志:CANCER RESEARCH
140.
Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma
发表年份:2021
来源杂志:CLINICAL CANCER RESEARCH
141.
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
发表年份:2021
来源杂志:Acta Pharmaceutica Sinica B
142.
TIGIT-Fc Promotes Antitumor Immunity
发表年份:2021
来源杂志:Cancer Immunology Research
143.
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
发表年份:2020-11-13
来源杂志:Frontiers in Immunology
144.
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation
发表年份:2020-05-19
来源杂志:NAT COMMUN
145.
Peptide Self-Assembly Nanoparticles Loaded with Panobinostat to Activate Latent Human Immunodeficiency Virus
发表年份:2019-05-01
来源杂志:J Biomed Nanotechnol
参考文献
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
来源杂志:nature communications
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