2210010C04Rik-D23A

品系全名

C57BL/6JSmo-2210010C04Rikem1D23ASmoc

目录号

NM-KI-232248

品系状态

精子冻存

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品系描述

该小鼠携带2210010C04Rik-D23A突变。

验证数据

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Fig 1. The pancreas of a heterozygous female mouse with RikD23A/+ mutation. 

Pancreatic tissue from 2-week-old and 23-week-old RikD23A/+ heterozygous female mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes.The scale bar corresponds to 200 µm.


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Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked

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Fig 2. The pancreas of a heterozygous male mouse with RikD23A/+ mutation

Pancreatic tissue from 4-week-old and 8-week-old RikD23A/+ heterozygous male mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes；The degree of fat infiltration and fibrosis is not significant in 2-week-old mice, and other phenotypes are mild.The scale bar corresponds to 200 µm.

image.png

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked


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