Customize your genetically engineered models
Since its establishment in September 2000, Shanghai Model Organisms Center (SMOC) strives to be the best-in-class resource center for biomedical researchers and industry partners, with its highly efficient and reliable technology platform.
Types of customization include:
Customized service process
Shanghai Model Organisms Center offers you:
In-depth feasibility evaluation before your project starts
More rational model design to avoid artifactual phenotypes
More detailed project feasibility assessment
More accurate timelines
An efficient production line with rigorous quality control
Shortened project trunaround time
Guaranteed germline transmission of genetic modification in models generated from the ES cell targeting and CRISPR gene editing technologies
Regular and rigorous reporting during project implementation
A dedicated project manager
Seamless flow of information
One-on-one, face-to-face communication
A professional breeding support team and advanced animal breeding facilities
Animal health reports
Global delivery
Flexible delivery options
热门文章
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
查看你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
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