Drd1-2A-CreERT2
品系全名
C57BL/6Smoc-Drd1em1(2A-CreERT2-WPRE-pA)Smoc
目录号
NM-KI-18016
品系状态
精子冻存
基因信息
基因名
Drd1
品系描述
A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Drd1 gene via homologous recombination to establish a tamoxifen inducible Drd1-CreERT2 tool stain. This strain can be used to knockout target gene in Drd1+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.
应用领域：Cre recombinase tool
*使用本品系发表的文献需注明: Drd1-2A-CreERT2 mice (Cat. NO. NM-KI-18016) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Figure 1：CreERT2-mediated recombination in brain of Drd1a CreERT2; R26 tdTomato mice. Detection of tdTomato (red) in brain of Drd1a CreERT2; R26 tdTomato mice.
Figure 2：CreERT2-mediated recombination in CPU(corpus striatum) of Drd1a CreERT2; R26 tdTomato mice. Detection of tdTomato (red) in CPU of Drd1a CreERT2; R26 tdTomato mice.
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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