Cpa1-N256K

Fig1. The pancreas of a heterozygous female mouse with Cpa1 N256K mutation.

The pancreas of 13.5-week-old Cpa1 N256K heterozygous female mice exhibited typical morphological changes, including acinar loss, inflammatory cell infiltration, acinar-ductal metaplasia, fibrosis, and some acinar cells showing vacuolation .The scale bar corresponds to 100 µm.

Pathology scores: 0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked

Fig2. The pancreas of a heterozygous male mouse with Cpa1 N256K mutation

The pancreatic tissue of 6-week-old and 13.5-week-old Cpa1 N256K heterozygous male mice showed a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fibrosis changes, and partial vacuolation of acinar cells.The scale bar corresponds to 100 µm.

Pathology scores: 0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked